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Familial aggregation of mucosal leishmaniasis in northeast Brazil
Journal article   Open access   Peer reviewed

Familial aggregation of mucosal leishmaniasis in northeast Brazil

Léa Castellucci, Lay Har Cheng, Cibele Araújo, Luiz Henrique Guimarães, Hélio Lessa, Paulo Machado, Mirela Frederico Almeida, Adja Oliveira, Albert Ko, Warren D Johnson, …
The American journal of tropical medicine and hygiene, Vol.73(1), pp.69-73
07/2005
DOI: 10.4269/ajtmh.2005.73.69
PMID: 16014836
url
https://doi.org/10.4269/ajtmh.2005.73.69View
Published (Version of record) Open Access

Abstract

To evaluate whether familial clustering occurs in mucosal leishmaniasis (ML), patients with ML (index cases) were randomly selected from medical records at a health post in an endemic area for Leishmania braziliensis infection. Control individuals (index controls) matched by age, gender, and place of residence to index cases were selected. Family members of index cases and controls were compared with respect to environmental factors and the incidence of cutaneous leishmaniasis (CL) and ML. Delayed type hypersensitivity test (DTH) to Leishmania antigen was tested in selected families. Among 289 members of 46 families enrolled, significant differences were found in the frequencies of CL (37% versus 20%) and ML (5% versus 0) in case versus control families, respectively. Families with 2 cases of ML had a higher frequency (29.6%) of DTH-positive individuals than control families (9.4%). These data demonstrate familial clustering of CL, ML, and positive DTH skin tests in an area endemic for L. braziliensis infection.
 Family Housing Leishmania braziliensis Leishmaniasis, Mucocutaneous - epidemiology Skin Tests Leishmaniasis, Mucocutaneous - transmission Humans Occupations Nuclear Family Male Environmental Exposure Animals Electricity Pedigree Adult Female Child Brazil - epidemiology

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