Journal article
Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
Bipolar disorders, Vol.10(1), pp.38-44
02/2008
DOI: 10.1111/j.1399-5618.2008.00455.x
PMCID: PMC6999822
PMID: 18199240
Abstract
Objectives: We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees.
Methods: A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipolar Disorder Collaborative Study and were asked whether they had ever experienced mood symptoms within four weeks postpartum. Women were also asked whether either of two major depressive episodes described in detail occurred postpartum. We examined the odds of postpartum mood symptoms in female siblings, who had previously been pregnant and had a diagnosis of bipolar I, bipolar II, or schizoaffective (bipolar type) disorders (n = 303), given one or more relatives with postpartum mood symptoms.
Results: The odds ratio for familial aggregation of postpartum mood symptoms was 2.31 (p = 0.011) in an Any Mood Symptoms analysis (n = 304) and increased to 2.71 (p = 0.005) when manic symptoms were excluded, though this was not significantly different from the Any Mood Symptoms analysis. We also examined familial aggregation of postpartum major depressive episodes; however, the number of subjects was small.
Conclusions: Limitations of the study include the retrospective interview, the fact that the data were collected for other purposes and the inability to control for such factors as medication use. Taken together with previous studies, these data provide support for the hypothesis that there may be a genetic basis for the trait of postpartum mood symptoms generally and postpartum depressive symptoms in particular in women with bipolar disorder. Genetic linkage and association studies incorporating this trait are warranted.
Details
- Title: Subtitle
- Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
- Creators
- Jennifer L Payne - Department of Psychiatry, University of Chicago, Chicago, IL, USADean F MacKinnon - Department of Psychiatry, University of Chicago, Chicago, IL, USAFrancis M Mondimore - Department of Psychiatry, University of Chicago, Chicago, IL, USAMelvin G McInnis - Department of Psychiatry, University of Chicago, Chicago, IL, USABarbara Schweizer - Department of Psychiatry, University of Chicago, Chicago, IL, USARachel B Zamoiski - Department of Psychiatry, University of Chicago, Chicago, IL, USAFrancis J McMahon - Department of Psychiatry, University of Chicago, Chicago, IL, USAJohn I Nurnberger - Department of Psychiatry, University of Chicago, Chicago, IL, USAJohn P Rice - Department of Psychiatry, University of Chicago, Chicago, IL, USAWilliam Scheftner - Department of Psychiatry, University of Chicago, Chicago, IL, USAWilliam Coryell - Department of Psychiatry, University of Chicago, Chicago, IL, USAWade H Berrettini - Department of Psychiatry, University of Chicago, Chicago, IL, USAJohn R Kelsoe - Department of Psychiatry, University of Chicago, Chicago, IL, USAWilliam Byerley - Department of Psychiatry, University of Chicago, Chicago, IL, USAElliot S Gershon - Department of Psychiatry, University of Chicago, Chicago, IL, USAJ Raymond DePaulo - Department of Psychiatry, University of Chicago, Chicago, IL, USAJames B Potash - Department of Psychiatry, University of Chicago, Chicago, IL, USA
- Resource Type
- Journal article
- Publication Details
- Bipolar disorders, Vol.10(1), pp.38-44
- DOI
- 10.1111/j.1399-5618.2008.00455.x
- PMID
- 18199240
- PMCID
- PMC6999822
- NLM abbreviation
- Bipolar Disord
- ISSN
- 1398-5647
- eISSN
- 1399-5618
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003415102771
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