Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry

Sampath Prahalad; Courtney E McCracken; Lori A Ponder; Sheila T Angeles-Han; Kelly A Rouster Stevens; Larry B Vogler; Carl D Langefeld; Susan D Thompson; CARRA Registry Investigators

doi:10.1186/s12969-016-0075-7

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Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry

Journal article

Open access

Peer reviewed

Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry

Sampath Prahalad, Courtney E McCracken, Lori A Ponder, Sheila T Angeles-Han, Kelly A Rouster Stevens, Larry B Vogler, Carl D Langefeld, Susan D Thompson and CARRA Registry Investigators

Pediatric rheumatology online journal, Vol.14(1), pp.14-14

03/10/2016

DOI: 10.1186/s12969-016-0075-7

PMCID: PMC4785640

PMID: 26965173

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Abstract

Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5 %) was less compared to subjects with JIA (31.8 %, p < 0.001) or SLE (31.9 %; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13 %) compared to cSLE (9.2 %, p = 0.007) or JDM (4.3 %, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1 % vs. 1.7 % for JIA and 1.1 % for JDM p < 0.001) or type-I diabetes (7.4 % for cSLE vs. 3.1 % for JIA and 3.0 % for JDM p < 0.001). Higher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.

Autoimmunity

Registries

United States - epidemiology

Prevalence

Rheumatology - statistics & numerical data

Humans

Child, Preschool

Male

Arthritis, Juvenile - immunology

Biomedical Research

Female

Retrospective Studies

Arthritis, Juvenile - epidemiology

Child

Details

Title: Subtitle: Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry
Creators: Sampath Prahalad - Children's Healthcare of Atlanta, Atlanta, GA, USA. sprahal@emory.edu
Courtney E McCracken - Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA
Lori A Ponder - Children's Healthcare of Atlanta, Atlanta, GA, USA
Sheila T Angeles-Han - Children's Healthcare of Atlanta, Atlanta, GA, USA
Kelly A Rouster Stevens - Children's Healthcare of Atlanta, Atlanta, GA, USA
Larry B Vogler - Children's Healthcare of Atlanta, Atlanta, GA, USA
Carl D Langefeld - Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Susan D Thompson - Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
CARRA Registry Investigators
Contributors: Polly J Ferguson (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Pediatric rheumatology online journal, Vol.14(1), pp.14-14
DOI: 10.1186/s12969-016-0075-7
PMID: 26965173
PMCID: PMC4785640
NLM abbreviation: Pediatr Rheumatol Online J
ISSN: 1546-0096
eISSN: 1546-0096
Publisher: England
Grant note: RC2-AR058934 / NIAMS NIH HHS 01-AR060893 / NIAMS NIH HHS P30 AR047363 / NIAMS NIH HHS P30-AR0470363 / NIAMS NIH HHS P01 AR048929 / NIAMS NIH HHS R01 AR060893 / NIAMS NIH HHS P01-AR048929 / NIAMS NIH HHS P30 AR070549 / NIAMS NIH HHS RC2 AR058934 / NIAMS NIH HHS
Language: English
Date published: 03/10/2016
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
Record Identifier: 9984065840302771

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