Familial epidermolysis bullosa acquisita

Megan H Noe; Mei Chen; David T Woodley; Janet A Fairley

doi:10.5070/D314b7543k

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Familial epidermolysis bullosa acquisita

Journal article

Open access

Peer reviewed

Familial epidermolysis bullosa acquisita

Megan H Noe, Mei Chen, David T Woodley and Janet A Fairley

Dermatology online journal, Vol.14(12), 2

12/15/2008

DOI: 10.5070/D314b7543k

PMID: 19265615

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Abstract

Epidermolysis bullosa acquisita (EBA) is an acquired blistering skin disorder caused by IgG autoantibodies directed against type VII collagen. In contrast to the genetic forms of epidermolysis bullosa, EBA is usually an acquired, sporadic disease. In this report, we describe a family with two cases of EBA in an uncle-nephew pair, and a third family member with asymptomatic circulating anti-type VII collagen antibodies. These findings provide support for the hypothesis that there is a genetic component to EBA.

Epidermolysis Bullosa Acquisita - immunology

Enzyme-Linked Immunosorbent Assay

Fluorescent Antibody Technique, Direct

Humans

Middle Aged

Collagen Type VII - immunology

Male

Microscopy, Immunoelectron

Epidermolysis Bullosa Acquisita - genetics

Aged, 80 and over

Autoantibodies - analysis

Female

Skin - pathology

Epidermolysis Bullosa Acquisita - pathology

Skin - immunology

Details

Title: Subtitle: Familial epidermolysis bullosa acquisita
Creators: Megan H Noe - Department of Dermatology, University of Iowa, Iowa City, Iowa, USA
Mei Chen
David T Woodley
Janet A Fairley
Resource Type: Journal article
Publication Details: Dermatology online journal, Vol.14(12), 2
DOI: 10.5070/D314b7543k
PMID: 19265615
NLM abbreviation: Dermatol Online J
eISSN: 1087-2108
Publisher: United States
Language: English
Date published: 12/15/2008
Academic Unit: Dermatology
Record Identifier: 9984025428202771

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