Journal article
Familial mediterranean Fever and renal disease
Saudi journal of kidney diseases and transplantation, Vol.14(3), pp.378-385
07/2003
PMID: 17657110
Appears in Diamond Open Access
Abstract
Familial Mediterranean Fever (FMF) is a genetic disorder frequently diagnosed among the Arabs. It is also prevalent among Jews, Armenians and Turks. The clinical picture consists of febrile and painful attacks such as joint or chest pain that differ in quality across patients and even within the same patient. The gene responsible for FMF, MEFV, has been cloned and mutations were identified within its coding sequence. It encodes a protein that is expected to be a down regulator of inflammation. The major renal involvement in FMF is the occurrence of amyloidosis that primarily affects the kidneys causing proteinuria and ending in death from renal failure. It can be treated by dialysis and renal transplantation, but can be prevented by a daily regimen of colchicine. Other renal manifestations of FMF are discussed.
Details
- Title: Subtitle
- Familial mediterranean Fever and renal disease
- Creators
- Hatem I El-Shanti - University of Iowa Hospitals and Clinics, Department of Pediatrics, Division of Medical Genetics, USA
- Resource Type
- Journal article
- Publication Details
- Saudi journal of kidney diseases and transplantation, Vol.14(3), pp.378-385
- PMID
- 17657110
- ISSN
- 1319-2442
- Language
- English
- Date published
- 07/2003
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984354405402771
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