Journal article
Familial mediterranean fever mutation analysis in pediatric patients with İnflammatory Bowel Disease: A multicenter study
The Turkish journal of gastroenterology, Vol.32(3), pp.248-260
03/01/2021
DOI: 10.5152/tjg.2021.20057
PMID: 34160354
Abstract
Background: The aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases has been reported previously. Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn’s disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined. Results: A total of 597 children (mean age: 10.8 ± 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/ heterozygous) in patients with UC (P < .05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P = .031, P = .045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P = .007). Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.
Details
- Title: Subtitle
- Familial mediterranean fever mutation analysis in pediatric patients with İnflammatory Bowel Disease: A multicenter study
- Creators
- Nafiye Urganci - Division of Pediatric Gastroenterology, Health Sciences University, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, TurkeyFunda Ozgenc - Ege UniversityZarife Kuloǧlu - Ankara UniversityHasan Yüksekkaya - Konya Food and Agriculture UniversitySinan Sari - Gazi UniversityTülay Erkan - Istanbul University-CerrahpaşaZerrin Önal - Sağlık Bilimleri ÜniversitesiGönül Çaltepe - Ondokuz Mayıs UniversityMustafa Akçam - Süleyman Demirel UniversityDuran Arslan - Erciyes UniversityNur Arslan - Dokuz Eylül UniversityReha Artan - Akdeniz UniversityAyşen Aydoǧan - Kocaeli ÜniversitesiNecati Balamtekin - Division of Pediatric Gastroenterology, Health Sciences University, Gulhane Training and Research Hospital, Ankara, TurkeyMaşallah Baran - Izmir UniversityGökhan Baysoy - Dicle UniversityMurat Çakir - Department of Pediatric Gastroenterology, Karadeniz University School of Medicine, Trabzon, TurkeyBuket Dalgiç - Gazi UniversityYaşar Doǧan - Ankara UniversityÖzlem Durmaz - Istanbul UniversityÇiǧdem Ecevit - Division of Pediatric Gastroenterology, Health Sciences University, Behçet Uz Training and Research Hospital, Izmir, TurkeyMakbule Eren - Eskişehir Osmangazi UniversitySelim Gökçe - Bezmiâlem Vakıf ÜniversitesiFulya Gülerman - Ankara UniversityFigen Gürakan - Amerikan HastanesiSamil Hizli - Gaziantep UniversityIshak Işik - Division of Pediatric Gastroenterology, Health Sciences University, Kayseri Training and Research Hospital, Kayseri, TurkeyAyhan Gazi Kalayci - Department of Pediatric Gastroenterology, Ondokuz Mayis University School of Medicine, Samsun, TurkeyAydan Kansu - Ankara UniversityTufan Kutlu - Istanbul University-CerrahpaşaHamza Karabiber - Inonu UniversityErhun Kasirga - Manisa Celal Bayar UniversityGünsel Kutluk - Sağlık Bilimleri ÜniversitesiFerdaǧ Özbay Hoşnut - Ministry of HealthHasan Özen - Hacettepe UniversityTanju Özkan - Bursa Uludağ Üni̇versi̇tesi̇Yeşim Öztürk - Dokuz Eylül UniversityÖzlem Bekem Soylu - Izmir UniversityEngin Tutar - Marmara UniversityGökhan Tümgör - Cukurova UniversityFatih Ünal - Bursa Technical UniversityMeltem Ugraş - Yeditepe UniversityGonca Üstündaǧ - Zonguldak Bülent Ecevit UniversityAytaç Yaman - Ministry of HealthTurkish IBD Study Grp
- Resource Type
- Journal article
- Publication Details
- The Turkish journal of gastroenterology, Vol.32(3), pp.248-260
- DOI
- 10.5152/tjg.2021.20057
- PMID
- 34160354
- ISSN
- 1300-4948
- eISSN
- 2148-5607
- Number of pages
- 13
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214171402771
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