Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response

Srinivas Balachander; Navya Spurthi Thatikonda; Anand Jose Kannampuzha; Mahashweta Bhattacharya; Sweta Sheth; Vinutha Ramesh; Alen Chandy Alexander; Moorthy Muthukumaran; Mino Susan Joseph; Sowmya Selvaraj; Dhruva Ithal; Vanteemar S Sreeraj; John P John; Ganesan Venkatasubramanian; Biju Viswanath; Yc Janardhan Reddy; Sanjeev Jain; ADBS consortium

doi:10.1016/j.jpsychires.2022.10.001

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Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response

Journal article

Peer reviewed

Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response

Srinivas Balachander, Navya Spurthi Thatikonda, Anand Jose Kannampuzha, Mahashweta Bhattacharya, Sweta Sheth, Vinutha Ramesh, Alen Chandy Alexander, Moorthy Muthukumaran, Mino Susan Joseph, Sowmya Selvaraj, …

Journal of psychiatric research, Vol.156, pp.557-563

12/01/2022

DOI: 10.1016/j.jpsychires.2022.10.001

PMCID: PMC7615106

PMID: 36368245

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https://www.ncbi.nlm.nih.gov/pmc/articles/7615106View

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Abstract

Family studies in obsessive-compulsive disorder (OCD) indicate higher rates of psychosis among their first-degree relatives (FDRs). However, the etiological and clinical relationships between the two disorders remain unclear. We compared the clinical characteristics and pharmacological treatment response in patients diagnosed with OCD with a family history of psychosis (OCD-FHP), with a family history of OCD (OCD-FHO) and those with sporadic OCD (OCD-S). A total of 226 patients who met DSM-IV criteria for OCD (OCD-FHP = 59, OCD-FHO = 112, OCD-S = 55) were included for analysis. All patients were evaluated using the Mini International Neuropsychiatric Interview (MINI 6.0.0), Yale-Brown Obsessive-Compulsive Scale (YBOCS), and the Family Interview for Genetic Studies (FIGS). Treatment response was characterized over naturalistic follow-up. The three groups did not differ across any demographic or clinical variables other than treatment response. Patients in the OCD-FHP group were found to have received a greater number of trials with serotonin reuptake inhibitors (SRI) [F (2,223) = 7.99, p < 0.001], were more likely to have failed ≥2 trials of SRIs (χ = 8.45, p = 0.014), and less likely to have attained remission (χ = 6.57, p = 0.037) CONCLUSIONS: We observed that having a relative with psychosis may predispose to treatment resistance in OCD. Further research on the influence of genetic liability to psychosis on treatment response in OCD may offer novel translational leads.

Genetic Predisposition to Disease

Humans

Obsessive-Compulsive Disorder - drug therapy

Obsessive-Compulsive Disorder - epidemiology

Obsessive-Compulsive Disorder - genetics

Details

Title: Subtitle: Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response
Creators: Srinivas Balachander - National Institute of Mental Health and Neurosciences
Navya Spurthi Thatikonda - National Institute of Mental Health and Neurosciences
Anand Jose Kannampuzha - National Institute of Mental Health and Neurosciences
Mahashweta Bhattacharya - National Institute of Mental Health and Neurosciences
Sweta Sheth - National Institute of Mental Health and Neurosciences
Vinutha Ramesh - National Institute of Mental Health and Neurosciences
Alen Chandy Alexander - Montreal Neurological Institute and Hospital
Moorthy Muthukumaran - National Institute of Mental Health and Neurosciences
Mino Susan Joseph - National Institute of Mental Health and Neurosciences
Sowmya Selvaraj - National Institute of Mental Health and Neurosciences
Dhruva Ithal - National Institute of Mental Health and Neurosciences
Vanteemar S Sreeraj - National Institute of Mental Health and Neurosciences
John P John - National Institute of Mental Health and Neurosciences
Ganesan Venkatasubramanian - National Institute of Mental Health and Neurosciences
Biju Viswanath - National Institute of Mental Health and Neurosciences
Yc Janardhan Reddy
Sanjeev Jain - National Institute of Mental Health and Neurosciences
ADBS consortium
Resource Type: Journal article
Publication Details: Journal of psychiatric research, Vol.156, pp.557-563
DOI: 10.1016/j.jpsychires.2022.10.001
PMID: 36368245
PMCID: PMC7615106
NLM abbreviation: J Psychiatr Res
ISSN: 0022-3956
eISSN: 1879-1379
Grant note: IA/CPHI/20/1/505266 / DBT-Wellcome Trust India Alliance
Language: English
Date published: 12/01/2022
Academic Unit: Psychiatry
Record Identifier: 9984843249502771

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