Journal article
Familiality and partitioning the variability of femoral bone mineral density in women of child-bearing age
Calcified tissue international, Vol.50(2), pp.110-114
01/01/1992
DOI: 10.1007/BF00298785
PMID: 1571827
Abstract
The contributions of polygenic loci and environmental factors to femoral bone mineral density (BMD in g/cm super(2)) variability were estimated in modified family sets consisting of women of child-bearing age. Femoral BMDs were measured in 535 women who were members of 137 family sets consisting minimally of an index, her sister, and unrelated female control. The family set could also include multiple sisters and first cousins. Women included in these family sets were all between 20 and 40 years of age to minimize the cohort effects of maturation and menopause on measures of BMD. BMDs were measured at three femoral sites using dual photon densitometry. Values were regressed on age and Quetelet Index which explained 13-15% of the variability in BMD (dependent on site). Subsequent variance components analysis on the residuals indicated that unmeasured polygenic loci accounted for substantial additional variability: 67% for femoral neck, 58% for Wards triangle, and 45% for trochanter.
Details
- Title: Subtitle
- Familiality and partitioning the variability of femoral bone mineral density in women of child-bearing age
- Creators
- MFR SowersM Boehnke - University of Michigan–Ann ArborM Jannausch - University of Michigan–Ann ArborM Crutchfield - University of Michigan–Ann ArborG Corton - University of Michigan–Ann ArborT Burns - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Calcified tissue international, Vol.50(2), pp.110-114
- DOI
- 10.1007/BF00298785
- PMID
- 1571827
- ISSN
- 0171-967X
- eISSN
- 1432-0827
- Language
- English
- Date published
- 01/01/1992
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363637702771
Metrics
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