Journal article
Family-Based Association Study of Neuregulin 1 With Psychotic Bipolar Disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.150B(5), pp.693-702
07/05/2009
DOI: 10.1002/ajmg.b.30895
PMCID: PMC4026923
PMID: 19127563
Abstract
The Neuregulin 1 gene (\nNRG1\n) has been associated with schizophrenia, and, to a lesser extent, with bipolar disorder (BP). We investigated the association of\nNRG1\nwith BP in a large family sample, and then performed analyses according to the presence of psychotic features or mood-incongruent psychotic features. We genotyped 116 tagSNPs and four Icelandic “core” SNPs in 1,199 subjects from 314 nuclear families. Of 515 BP offspring, 341 had psychotic features, and 103 had mood-incongruent psychotic features. In single-marker and sliding window haplotype analyses using FBAT, there was little association using the standard BP or mood-incongruent psychotic BP phenotypes, but stronger signals were seen in the psychotic BP phenotype. The most significant associations with psychotic BP were in haplotypes within the 5′ “core” region. The strongest global\nP\n-value was across three SNPs: NRG241930-NRG243177-rs7819063 (\nP\n=0.0016), with an undertransmitted haplotype showing an individual\nP\n=0.0007. The most significant individual haplotype was an undertransmitted two-allele subset of the above (NRG243177-rs7819063,\nP\n=0.0004). Additional associations with psychotic BP were found across six SNPs in a 270 kb central region of the gene. The most 3′ of these, rs7005606 (\nP\n=0.0029), is located ∼4 kb from the type I\nNRG1\nisoform promoter. In sum, our study suggests that\nNRG1\nmay be specifically associated with the psychotic subset of BP; however, our results should be interpreted cautiously since they do not meet correction for multiple testing and await independent replication.
Details
- Title: Subtitle
- Family-Based Association Study of Neuregulin 1 With Psychotic Bipolar Disorder
- Creators
- Fernando S Goes - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandVirginia L Willour - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandPeter P Zandi - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandPamela L Belmonte - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandDean F MacKinnon - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandFrancis M Mondimore - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandBarbara Schweizer - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MarylandElliot S Gershon - Department of Psychiatry, University of Chicago, Chicago, IllinoisFrancis J McMahon - Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MarylandJames B Potash - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.150B(5), pp.693-702
- DOI
- 10.1002/ajmg.b.30895
- PMID
- 19127563
- PMCID
- PMC4026923
- NLM abbreviation
- Am J Med Genet B Neuropsychiatr Genet
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Language
- English
- Date published
- 07/05/2009
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070631002771
Metrics
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