Journal article
Family-based Genome-wide Association Study of Frontal Theta Oscillations Identifies Potassium Channel Gene KCNJ6
Genes, brain and behavior, Vol.11(6), pp.712-719
08/2012
DOI: 10.1111/j.1601-183X.2012.00803.x
PMCID: PMC3666338
PMID: 22554406
Abstract
Event-related oscillations (EROs) represent highly heritable neuroelectric correlates of cognitive processes that manifest deficits in alcoholics and in offspring at high risk to develop alcoholism. Theta ERO to targets in the visual oddball task has been shown to be an endophenotype for alcoholism. A family-based genome-wide association study was performed for the frontal theta ERO phenotype using 634583 autosomal single nucleotide polymorphisms (SNPs) genotyped in 1560 family members from 117 families densely affected by alcohol use disorders, recruited in the Collaborative Study on the Genetics of Alcoholism. Genome-wide significant association was found with several SNPs on chromosome 21 in
Details
- Title: Subtitle
- Family-based Genome-wide Association Study of Frontal Theta Oscillations Identifies Potassium Channel Gene KCNJ6
- Creators
- Sun J Kang - Department of Psychiatry, University of California-San Diego, La Jolla, CAMadhavi Rangaswamy - Department of Psychiatry, University of California-San Diego, La Jolla, CANiklas Manz - Department of Psychiatry, University of California-San Diego, La Jolla, CAJen-Chyong Wang - Department of Psychiatry, University of California-San Diego, La Jolla, CALeah Wetherill - Department of Psychiatry, University of California-San Diego, La Jolla, CATony Hinrichs - Department of Psychiatry, University of California-San Diego, La Jolla, CALaura Almasy - Department of Psychiatry, University of California-San Diego, La Jolla, CAAndy Brooks - Department of Psychiatry, University of California-San Diego, La Jolla, CADavid B Chorlian - Department of Psychiatry, University of California-San Diego, La Jolla, CADanielle Dick - Department of Psychiatry, University of California-San Diego, La Jolla, CAVictor Hesselbrock - Department of Psychiatry, University of California-San Diego, La Jolla, CAJohn Kramer - Department of Psychiatry, University of California-San Diego, La Jolla, CASam Kuperman - Department of Psychiatry, University of California-San Diego, La Jolla, CAJohn Nurnberger - Department of Psychiatry, University of California-San Diego, La Jolla, CAJohn Rice - Department of Psychiatry, University of California-San Diego, La Jolla, CAMarc Schuckit - Department of Psychiatry, University of California-San Diego, La Jolla, CAJay Tischfield - Department of Psychiatry, University of California-San Diego, La Jolla, CALaura J Bierut - Department of Psychiatry, University of California-San Diego, La Jolla, CAHoward J Edenberg - Department of Psychiatry, University of California-San Diego, La Jolla, CAAlison Goate - Department of Psychiatry, University of California-San Diego, La Jolla, CATatiana Foroud - Department of Psychiatry, University of California-San Diego, La Jolla, CABernice Porjesz - Department of Psychiatry, University of California-San Diego, La Jolla, CA
- Resource Type
- Journal article
- Publication Details
- Genes, brain and behavior, Vol.11(6), pp.712-719
- DOI
- 10.1111/j.1601-183X.2012.00803.x
- PMID
- 22554406
- PMCID
- PMC3666338
- ISSN
- 1601-1848
- eISSN
- 1601-183X
- Grant note
- U10 AA008401 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003987402771
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