Journal article
Family-based SNP Association Study on 8q24 in Bipolar Disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.147B(5), pp.612-618
07/05/2008
DOI: 10.1002/ajmg.b.30651
PMCID: PMC2700285
PMID: 18163389
Abstract
Previous linkage studies have identified chromosome 8q24 as a promising positional candidate region to search for bipolar disorder (BP) susceptibility genes. We, therefore, sought to identify BP susceptibility genes on chromosome 8q24 using a family-based association study of a dense panel of SNPs selected to tag the known common variation across the region of interest. A total of 1,458 SNPs across 16 Mb of 8q24 were examined in 3,512 subjects, 1,954 of whom were affected with BP, from 737 multiplex families. Single-locus tests were carried out with FBAT and Geno-PDT, and multi-locus test were carried out with HBAT and multi-locus Geno-PDT. None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (p<3.00×10
−5
). However, there was consistent evidence at our threshold for the suggestive level (p<7.00×10
−4
) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1 and NSE2. Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 (p=3.00×10
−4
), with at least one copy of the “high risk” allele required at both genes for association with BP, consistent with a jointly dominant-dominant model of action. These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility.
Details
- Title: Subtitle
- Family-based SNP Association Study on 8q24 in Bipolar Disorder
- Creators
- Peter P Zandi - Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, MDSebastian Zoellner - Department of Psychiatry, University of Michigan, Ann Arbor, MIDimitrios Avramopoulos - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MDVirginia L Willour - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MDYi Chen - Department of Psychiatry, University of Michigan, Ann Arbor, MIZhaohui S Qin - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MIMargit Burmeister - Molecular & Behavioral Neurosciences Institute, Psychiatry and Human Genetics, University of Michigan, Ann Arbor, MIKuangyi Miao - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MDShyam Gopalakrishnan - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MIRichard McEachin - Department of Psychiatry, University of Michigan, Ann Arbor, MIJames B Potash - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MDJ. Raymond DePaulo - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MDMelvin G McInnis - Department of Psychiatry, University of Michigan, Ann Arbor, MI
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.147B(5), pp.612-618
- DOI
- 10.1002/ajmg.b.30651
- PMID
- 18163389
- PMCID
- PMC2700285
- NLM abbreviation
- Am J Med Genet B Neuropsychiatr Genet
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Language
- English
- Date published
- 07/05/2008
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070608202771
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