Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1

Danielle M Dick; Jen C Wang; Jevon Plunkett; Fazil Aliev; Anthony Hinrichs; Sarah Bertelsen; John P Budde; Elianna L Goldstein; Daniel Kaplan; Howard J Edenberg; John  Nurnberger Jr; Victor Hesselbrock; Marc Schuckit; Sam Kuperman; Jay Tischfield; Bernice Porjesz; Henri Begleiter; Laura Jean Bierut; Alison Goate

doi:10.1111/j.1530-0277.2007.00470.x

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Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1

Journal article

Peer reviewed

Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1

Danielle M Dick, Jen C Wang, Jevon Plunkett, Fazil Aliev, Anthony Hinrichs, Sarah Bertelsen, John P Budde, Elianna L Goldstein, Daniel Kaplan, Howard J Edenberg, …

Alcoholism, clinical and experimental research, Vol.31(10), pp.1645-1653

10/2007

DOI: 10.1111/j.1530-0277.2007.00470.x

PMID: 17850642

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Abstract

There is an extensive and inconsistent literature on the association of the dopamine D2 receptor gene (DRD2) with alcohol dependence. Conflicting results have been attributed to differences in the severity of the alcohol dependence phenotype across studies, failure to exclude related disorders from comparison groups, and artifacts of population-stratification. Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene, ankyrin repeat and kinase domain containing 1 (ANKK1), located 10 kb downstream from DRD2.

Phenotype

Severity of Illness Index

European Continental Ancestry Group - genetics

Disease Susceptibility

Protein-Serine-Threonine Kinases - physiology

Gene Frequency

Humans

Protein-Serine-Threonine Kinases - genetics

Genotype

Male

Receptors, Dopamine D2 - genetics

Linkage Disequilibrium

Polymorphism, Single Nucleotide - genetics

Alcoholism - genetics

Female

Receptors, Dopamine D2 - physiology

Signal Transduction - physiology

Alcoholism - physiopathology

Details

Title: Subtitle: Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
Creators: Danielle M Dick - Washington University in St Louis, St Louis, Missouri, USA. ddick@vcu.edu
Jen C Wang
Jevon Plunkett
Fazil Aliev
Anthony Hinrichs
Sarah Bertelsen
John P Budde
Elianna L Goldstein
Daniel Kaplan
Howard J Edenberg
John Nurnberger Jr
Victor Hesselbrock
Marc Schuckit
Sam Kuperman
Jay Tischfield
Bernice Porjesz
Henri Begleiter
Laura Jean Bierut
Alison Goate
Resource Type: Journal article
Publication Details: Alcoholism, clinical and experimental research, Vol.31(10), pp.1645-1653
DOI: 10.1111/j.1530-0277.2007.00470.x
PMID: 17850642
NLM abbreviation: Alcohol Clin Exp Res
ISSN: 0145-6008
eISSN: 1530-0277
Publisher: Wiley; England
Grant note: U10AA08401 / NIAAA NIH HHS
Language: English
Date published: 10/2007
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003435002771

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