Journal article
Family history and prostate cancer risk in a population-based cohort of Iowa men
Cancer epidemiology, biomarkers & prevention, Vol.8(1), pp.53-60
01/1999
PMID: 9950240
Abstract
A family history of prostate cancer has been associated with prostate cancer risk in most prior studies, and more limited data suggest that a family history of breast cancer may also be important; however, there are no data from a population-based cohort study of prostate cancer incidence that adjusts for major confounders. We conducted follow-up through 1995 on 1557 men, ages 40-86 years, who were randomly selected (81% response rate) as cancer-free controls for a population-based case-control study conducted in Iowa from 1987-1989. Family history of cancer in parents and siblings was obtained using a mailed questionnaire. Incident cancers and deaths were ascertained through linkages to state and national databases; 101 incident cases of prostate cancer were identified. At baseline, 4.6% of the cohort reported a family history of prostate cancer in a brother or father, and this was positively associated with prostate cancer risk after adjustment for age [relative risk (RR) = 3.2; 95% confidence interval (CI), 1.8-5.7] or after multivariate adjustment for age, alcohol, and dietary factors (RR = 3.7; 95% CI, 1.9-7.2). Risk was greater if a brother had prostate cancer (RR = 4.5; 95% CI, 2.1-9.7) than if a father had prostate cancer (RR = 2.3; 95% CI, 1.0-5.3). Also at baseline, 9.6% of the cohort had a family history of breast and/or ovarian cancer in a mother or sister, and this was positively associated with prostate cancer risk (age-adjusted RR = 1.7; 95% CI, 1.0-3.0; multivariate RR = 1.7; 95% CI, 0.9-3.2). Men with a family history of both prostate and breast/ovarian cancer were also at increased risk of prostate cancer (RR = 5.8; 95% CI, 2.4-14). There was no association with a family history of colon cancer. Exclusion of well-differentiated, localized tumors did not alter these findings. These data from an incidence study confirm that a family history of prostate cancer is a strong prostate cancer risk factor after adjustment for dietary and other risk factors, and suggest that selection and recall bias have not had an important influence on most case-control study results. These data also support the idea that a family history of breast cancer may also be a prostate cancer risk factor.
Details
- Title: Subtitle
- Family history and prostate cancer risk in a population-based cohort of Iowa men
- Creators
- James R Cerhan - Department of Preventive Medicine, The University of Iowa College of Medicine, Iowa City 52242, USA. cerhan.james@mayo.eduAlexander S Parker - University of IowaShannon D PutnamBrian C.-H ChiuCharles F LynchMichael B CohenJames C TornerKenneth P Cantor
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.8(1), pp.53-60
- PMID
- 9950240
- NLM abbreviation
- Cancer Epidemiol Biomarkers Prev
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Publisher
- United States
- Grant note
- R21 CA/ES69838 / NCI NIH HHS N01-CP-51026 / NCI NIH HHS N01-CP-85614 / NCI NIH HHS
- Language
- English
- Date published
- 01/1999
- Academic Unit
- Epidemiology; Pathology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995157802771
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