Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study

Rongling Li; Mary J O'Sullivan; Jennifer Robinson; Monika M Safford; David Curb; Karen C Johnson

doi:10.1002/dmrr.1010

Back

Journal article

Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study

Rongling Li, Mary J O'Sullivan, Jennifer Robinson, Monika M Safford, David Curb and Karen C Johnson

Diabetes/metabolism research and reviews, Vol.25(8), pp.725-732

11/2009

DOI: 10.1002/dmrr.1010

PMCID: PMC4478605

PMID: 19780066

Files and links (1)

url

http://doi.org/10.1002/dmrr.1010View

Open Access

Abstract

Diabetes is a risk factor for coronary heart disease (CHD) but CHD does not occur in all diabetic individuals. The goal of this study was to assess the relationship between family history of myocardial infarction (MI) and incident CHD in diabetic postmenopausal women. We conducted a prospective cohort study among 2642 diabetic postmenopausal women without CHD at baseline in the Women's Health Initiative Observational Study. Family history was defined as a proband report of MI in first-degree relatives. Incident CHD was defined as non-fatal MI, coronary revascularization, or CHD death. During 7.3 ( +/- 1.8) years of follow-up, 14.3% of the participants had incident CHD. The risk of incident CHD was 50% higher (HR = 1.50, 95% CI: 1.20-1.87, p = 0.0003) in those with a family history of an MI in at least one first-degree relative, and 79% higher (HR = 1.79, 95% CI: 1.36-2.35, P < 0.0001) if two or more first-degree relatives had an MI, compared to participants without a family history, after adjustment for covariates. The CHD risk increased with elevated systolic blood pressure (SBP) (HR = 1.01, 95% CI: 1.003-1.02, p = 0.001) but decreased with elevated diastolic BP (HR = 0.98, 95% CI: 0.97-0.999, p = 0.005) and with two or more episodes per week of physical activity (HR = 0.70, 95% CI: 0.52-0.93, p = 0.02). The results suggest that a family history of MI predicts CHD in diabetic postmenopausal women. Close attention should be paid to BP control and physical activity in these women.

Blood Pressure

Myocardial Infarction - genetics

Predictive Value of Tests

Genetic Predisposition to Disease

Prospective Studies

Diabetes Complications - physiopathology

United States

Humans

Middle Aged

Risk Factors

Diabetes Mellitus - drug therapy

Coronary Disease - etiology

Family Health

Statistics as Topic

Motor Activity

Coronary Disease - prevention & control

Postmenopause

Female

Surveys and Questionnaires

Aged

Details

Title: Subtitle: Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study
Creators: Rongling Li - University of Tennessee Health Science Center, Department of Preventive Medicine, Memphis, TN, USA. lir2@mail.nih.gov
Mary J O'Sullivan
Jennifer Robinson
Monika M Safford
David Curb
Karen C Johnson
Resource Type: Journal article
Publication Details: Diabetes/metabolism research and reviews, Vol.25(8), pp.725-732
DOI: 10.1002/dmrr.1010
PMID: 19780066
PMCID: PMC4478605
NLM abbreviation: Diabetes Metab Res Rev
ISSN: 1520-7560
eISSN: 1520-7560
Publisher: England
Grant note: N01-WH-3-2118 / WHI NIH HHS N01-WH-4-2118 / WHI NIH HHS R01 HL080477 / NHLBI NIH HHS N01-WH-3-2100 / WHI NIH HHS N01 WH032118 / WHI NIH HHS N01-WH-4-2113 / WHI NIH HHS N01-WH-3-2113 / WHI NIH HHS N01-WH-4-2114 / WHI NIH HHS N01-WH-4-2123 / WHI NIH HHS N01-WH-4-2132 / WHI NIH HHS N01-WH-4-2108 / WHI NIH HHS N01-WH-3-2108 / WHI NIH HHS N01-WH-3-2119 / WHI NIH HHS N01-WH-4-2119 / WHI NIH HHS N01-WH-4-2110 / WHI NIH HHS N01-WH-3-2110 / WHI NIH HHS N01-WH-3-2101 / WHI NIH HHS N01-WH-4-2115 / WHI NIH HHS N01-WH-3-2105 / WHI NIH HHS N01-WH-4-2124 / WHI NIH HHS N01-WH-3-2109 / WHI NIH HHS N01-WH-3-2120 / WHI NIH HHS N01-WH-4-2120 / WHI NIH HHS N01-WH-4-2109 / WHI NIH HHS N01-WH-3-2102 / WHI NIH HHS N01-WH-4-2111 / WHI NIH HHS N01-WH-3-2111 / WHI NIH HHS N01-WH-4-2116 / WHI NIH HHS N01-WH-4-2129 / WHI NIH HHS N01-WH-4-2130 / WHI NIH HHS N01-WH-3-2106 / WHI NIH HHS N01-WH-3-2115 / WHI NIH HHS N01-WH-4-2125 / WHI NIH HHS N01-WH-4-2121 / WHI NIH HHS N01-WH-4-2126 / WHI NIH HHS N01-WH-4-2117 / WHI NIH HHS N01-WH-4-2112 / WHI NIH HHS N01-WH-3-2112 / WHI NIH HHS N01-WH-3-2122 / WHI NIH HHS N01-WH-4-2122 / WHI NIH HHS N01-WH-4-2107 / WHI NIH HHS N01-WH-4-2131 / WHI NIH HHS
Language: English
Date published: 11/2009
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995112102771

Metrics

33 Record Views

9 Times Cited - Web of Science