Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila

Takaomi Sakai; Show Inami; Shoma Sato; Toshihiro Kitamoto

doi:10.1101/lm.028092.112

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Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila

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Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila

Takaomi Sakai, Show Inami, Shoma Sato and Toshihiro Kitamoto

Learning & memory (Cold Spring Harbor, N.Y.), Vol.19(12), pp.571-574

12/2012

DOI: 10.1101/lm.028092.112

PMCID: PMC3506976

PMID: 23154928

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Abstract

In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period ( per ) also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) overexpression and knocking down of per in subsets of brain neurons enhance and suppress LTM, respectively, and (2) suppression of synaptic transmission during memory retrieval in the same neuronal subsets leads to defective LTM. Further analysis strongly suggests that the brain region critical for per -dependent LTM regulation is the fan-shaped body, which is involved in sleep-induced enhancement of courtship LTM.

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Title: Subtitle: Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila
Creators: Takaomi Sakai - Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan
Show Inami - Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan
Shoma Sato - Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan
Toshihiro Kitamoto - Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: Learning & memory (Cold Spring Harbor, N.Y.), Vol.19(12), pp.571-574
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/lm.028092.112
PMID: 23154928
PMCID: PMC3506976
ISSN: 1072-0502
eISSN: 1549-5485
Alternative title: FB neurons are involved in period-dependent memory
Language: English
Date published: 12/2012
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006483002771

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