Journal article
Fanconi's Anemia and Primary Hypothyroidism
Annals of Saudi medicine, Vol.18(1), pp.58-59
01/1998
DOI: 10.5144/0256-4947.1998.58
PMID: 17341919
Abstract
Fanconi's anemia (FA) is an autosomal recessive disorder marked by bone marrow hypoplasia, a variety of congenital anomalies involving skin, heart, genitourinary tract, skeletal system, central nervous system, growth and mental retardation.1 As early as 1960, Nilsson pointed out that some features of FA, such as crypto-orchidism, abnormal pigmentation and stunted growth, may be related to endocrine dysfunction.2 This information was obtained by reviewing 68 individuals with FA, as well as two necropsies. However, growth hormone deficiency in FA patients was first documented about 10 years later.3 Several other endocrinological abnormalities were reported as well, which included adrenocorticotropic hormone (ACTH), gonadotropin deficiency and missing insulin release following arginine stimulation.3–11 There is only one known report referring to the thyroid gland problem in the literature.12 We report here the presence of primary hypothyroidism in two patients with FA.
Details
- Title: Subtitle
- Fanconi's Anemia and Primary Hypothyroidism
- Creators
- Mahmoud Al-Sheyyab - Jordan University of Science and TechnologyHatem El-Shanti - Jordan University of Science and TechnologyNayef Ghariebeh - Jordan University of Science and TechnologyFaisal Ektiesh - Jordan University of Science and TechnologyAzhar S. Daoud - Jordan University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Annals of Saudi medicine, Vol.18(1), pp.58-59
- DOI
- 10.5144/0256-4947.1998.58
- PMID
- 17341919
- ISSN
- 0256-4947
- eISSN
- 0975-4466
- Language
- English
- Date published
- 01/1998
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984353929102771
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