Journal article
Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study
Journal of cardiovascular electrophysiology, Vol.24(6), pp.640-648
06/2013
DOI: 10.1111/jce.12105
PMID: 23437865
Abstract
Left Ventricular Tachycardia in Pediatrics
Introduction
The aim of this study was to evaluate the clinical presentation and outcomes of pediatric patients with ventricular tachycardia (VT) originating from left heart structures.
Methods and Results
This international multicenter retrospective study including 152 patients (age 10.0 ± 5.1 years, 62% male), divided into those with fascicular VT (85%, 129/152) and nonfascicular LV VT (15%, 23/152). All patients had a normal heart structure or only a minor cardiac abnormality. Adenosine was largely ineffective in both groups (tachycardia termination in 4/74 of fascicular VT and 0/5 of nonfascicular LV VT). In fascicular VT, calcium channel blockers were effective in 80% (74/92); however, when administered orally, there was a 21% (13/62) recurrence rate. In nonfascicular LV VT, a variety of antiarrhythmic therapies were used with no one predominating. Ablation procedures were successful in 71% (72/102) of fascicular VT and 67% (12/18) of nonfascicular LV VT on an intention to treat analysis. Major complications occurred in 5 patients with fascicular VT and 1 patient with nonfascicular LV VT. After a follow‐up period of 2 years (1 day to 15 years), 72% of all patients with fascicular VT were off medications with no tachycardia recurrence. One patient died of noncardiac causes. In nonfascicular LV VT, follow‐up was 3.5 years (0.5–15 years), P = 0.38. A total of 65% of these patients were free from arrhythmias. Two patients died suddenly (P < 0.01).
Conclusion
The clinical course and outcomes of pediatric patients with fascicular VT and nonfascicular LV VT are varied. Catheter ablation procedures can be curative.
Details
- Title: Subtitle
- Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study
- Creators
- KATHRYN K COLLINS - The Children's Hospital, University of ColoradoIAN H LAW - University of Iowa Children's HospitalMICHAEL S SCHAFFER - The Children's Hospital, University of ColoradoPediatric and Congenital Electrophysiology SocietyELIZABETH SAAREL - Primary Children's HospitalMARIA KNECHT - The Children's Memorial Health InsituteRONN E TANEL - University of CaliforniaDAVID BRADLEY - C. S. Mott Children's HospitalANNE M DUBIN - Stanford UniversityTHOMAS PAUL - Georg‐August‐UniversityJACK SALERNO - Children's Heart CenterYANIV BAR‐COHEN - Children's HospitalNARAYANSWAMI SREERAM - University Hospital of CologneSHUBHAYAN SANATANI - British Columbia Children's HospitalANDREW BLAUFOX - Steven and Alexandra Cohen Children's Medical Center of New YorkANJAN BATRA - University of California‐IrvineJOSE M MOLTEDO - Clinica y Maternidad Suizo ArgentinaGEORGE F VAN HARE - Washington University School of Medicine/St. Louis Children's HospitalJOHN REED - Medical University of South CarolinaPAMELA S RO - Nationwide Children's HospitalJOHN KUGLER - Nebraska Medical CenterCHRIS ANDERSON - Northwest Center for Congenital Heart DiseaseJOHN K TRIEDMAN - Children's HospitalPediat & Congenital Electrophysiol
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular electrophysiology, Vol.24(6), pp.640-648
- DOI
- 10.1111/jce.12105
- PMID
- 23437865
- ISSN
- 1045-3873
- eISSN
- 1540-8167
- Number of pages
- 9
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984093221302771
Metrics
29 Record Views