Journal article
Fascin in Cell Migration: More Than an Actin Bundling Protein
Biology (Basel, Switzerland), Vol.9(11), pp.1-18
11/01/2020
DOI: 10.3390/biology9110403
PMCID: PMC7698196
PMID: 33212856
Abstract
Fascin, an actin-binding protein, regulates many developmental migrations and contributes to cancer metastasis. Specifically, Fascin promotes cell motility, invasion, and adhesion by forming filopodia and invadopodia through its canonical actin bundling function. In addition to bundling actin, Fascin has non-canonical roles in the cell that are thought to promote cell migration. These non-canonical functions include regulating the activity of other actin-binding proteins, binding to and regulating microtubules, mediating mechanotransduction to the nucleus via interaction with the Linker of the Nucleoskeleton and Cytoskeleton (LINC) Complex, and localizing to the nucleus to regulate nuclear actin, the nucleolus, and chromatin modifications. The many functions of Fascin must be coordinately regulated to control cell migration. While much remains to be learned about such mechanisms, Fascin is regulated by post-translational modifications, prostaglandin signaling, protein-protein interactions, and transcriptional means. Here, we review the structure of Fascin, the various functions of Fascin and how they contribute to cell migration, the mechanisms regulating Fascin, and how Fascin contributes to diseases, specifically cancer metastasis.
Details
- Title: Subtitle
- Fascin in Cell Migration: More Than an Actin Bundling Protein
- Creators
- Maureen C. Lamb - Roy J. and Lucille A. Carver College of MedicineTina L. Tootle - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Biology (Basel, Switzerland), Vol.9(11), pp.1-18
- DOI
- 10.3390/biology9110403
- PMID
- 33212856
- PMCID
- PMC7698196
- NLM abbreviation
- Biology (Basel)
- ISSN
- 2079-7737
- eISSN
- 2079-7737
- Publisher
- Mdpi
- Number of pages
- 18
- Grant note
- R01GM116885 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA University of Iowa Summer Graduate Fellowship
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984284452002771
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