Journal article
Faster‐X evolution of gene expression is driven by recessive adaptive cis‐regulatory variation in Drosophila
Molecular ecology, Vol.27(19), pp.3811-3821
10/2018
DOI: 10.1111/mec.14708
PMID: 29717553
Abstract
The hemizygosity of the X (Z) chromosome fully exposes the fitness effects of mutations on that chromosome and has evolutionary consequences on the relative rates of evolution of X and autosomes. Specifically, several population genetics models predict increased rates of evolution in X‐linked loci relative to autosomal loci. This prediction of faster‐X evolution has been evaluated and confirmed for both protein coding sequences and gene expression. In the case of faster‐X evolution for gene expression divergence, it is often assumed that variation in 5′ noncoding sequences is associated with variation in transcript abundance between species but a formal, genomewide test of this hypothesis is still missing. Here, I use whole genome sequence data in Drosophila yakuba and D. santomea to evaluate this hypothesis and report positive correlations between sequence divergence at 5′ noncoding sequences and gene expression divergence. I also examine polymorphism and divergence in 9,279 noncoding sequences located at the 5′ end of annotated genes and detected multiple signals of positive selection. Notably, I used the traditional synonymous sites as neutral reference to test for adaptive evolution, but I also used bases 8–30 of introns <65 bp, which have been proposed to be a better neutral choice. X‐linked genes with high degree of male‐biased expression show the most extreme adaptive pattern at 5′ noncoding regions, in agreement with faster‐X evolution for gene expression divergence and a higher incidence of positively selected recessive mutations.
Details
- Title: Subtitle
- Faster‐X evolution of gene expression is driven by recessive adaptive cis‐regulatory variation in Drosophila
- Creators
- Ana Llopart - The University of Iowa
- Resource Type
- Journal article
- Publication Details
- Molecular ecology, Vol.27(19), pp.3811-3821
- DOI
- 10.1111/mec.14708
- PMID
- 29717553
- NLM abbreviation
- Mol Ecol
- ISSN
- 0962-1083
- eISSN
- 1365-294X
- Number of pages
- 11
- Grant note
- National Science Foundation (DEB1354921)
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Biology
- Record Identifier
- 9984217417002771
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