Journal article
Fatigability, oxygen uptake kinetics and muscle deoxygenation in incomplete spinal cord injury during treadmill walking
European journal of applied physiology, Vol.117(10), pp.1989-2000
10/2017
DOI: 10.1007/s00421-017-3685-y
PMID: 28744558
Abstract
The purpose of the present study was to characterize hypothesized relationships among fatigability and cardiorespiratory fitness in individuals with chronic motor-incomplete SCI (iSCI) during treadmill walking. The theoretical framework was that exacerbated fatigability would occur concomitantly with diminished cardiorespiratory fitness in people with iSCI.
Subjects with iSCI (n = 8) and an able-bodied reference group (REF) (n = 8) completed a 6-min walking bout followed by a walking bout of 30-min or until volitional exhaustion, both at a self-selected walking speed. Fatigability was assessed using both perceived fatigability and performance fatigability measures. Pulmonary oxygen uptake kinetics (VO
on-kinetics) was measured breath-by-breath and changes in deoxygenated hemoglobin/myoglobin concentration (∆[HHb]) of the lateral gastrocnemius was measured by near-infrared spectroscopy. Adjustment of VO
and ∆[HHb] on-kinetics were modeled using a mono-exponential equation.
Perceived fatigability and performance fatigability were 52% and 44% greater in the iSCI group compared to the REF group (p = 0.003 and p = 0.004). Phase II time constant (τp) of VO
on-kinetics and ∆[HHb] ½ time during resting arterial occlusion were 55.4% and 16.3% slower in iSCI vs REF (p < 0.01 and p = 0.047, respectively).
The results of the present study may suggest that compromised O
delivery and/or utilization may have contributed to the severity of fatigability in these individuals with iSCI. The understanding of the extent to which fatigability and VO
and Δ[HHb] on-kinetics impacts locomotion after iSCI will assist in the future development of targeted interventions to enhance function.
Details
- Title: Subtitle
- Fatigability, oxygen uptake kinetics and muscle deoxygenation in incomplete spinal cord injury during treadmill walking
- Creators
- Jared M Gollie - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USA. jgollie@gmu.eduJeffrey E Herrick - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USARandall E Keyser - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USALisa M K Chin - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USAJohn P Collins - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USARichard K Shields - Department of Physical Therapy and Rehabilitation Sciences, University of Iowa, Iowa, USAGino S Panza - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USAAndrew A Guccione - Department of Rehabilitation Science, George Mason University, 4400 University Drive MS2G7, Fairfax, VA, 22030, USA
- Resource Type
- Journal article
- Publication Details
- European journal of applied physiology, Vol.117(10), pp.1989-2000
- Publisher
- Germany
- DOI
- 10.1007/s00421-017-3685-y
- PMID
- 28744558
- ISSN
- 1439-6319
- eISSN
- 1439-6327
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047692702771
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