Journal article
Fatigue and Sleep Quality before and after Liver Transplantation
Progress in transplantation (Aliso Viejo, Calif.), Vol.20(3), pp.221-233
09/2010
DOI: 10.1177/152692481002000305
PMID: 20929106
Abstract
Context
Recent publications suggest that fatigue and sleep disturbance are problems in patients with chronic liver disease and in liver transplant recipients.
Objectives
To characterize the severity and nature of fatigue and sleep quality before and after liver transplantation, to examine the relationship between fatigue/sleep quality and quality of life, and to identify their multivariate correlates.
Design, Settings, and Participants
Cross-sectional survey administered to 110 patients before and 95 patients after liver transplantation at 2 transplant centers.
Main Outcome Measures
Fatigue and sleep quality.
Results
Most pretransplant (86%) and posttransplant (76%) patients experienced high fatigue severity. Correlates of pretransplant fatigue severity were being female (odds ratio [OR] = 0.22, P= .04), higher body mass index (OR = 1.07, P= .04), higher mood disturbance (OR=1.05, P= .02), and poor sleep quality (OR=0.26, P= .02). Correlates of posttransplant fatigue severity were use of sleep medications in the past month (OR = 0.51, P= .02) and higher mood disturbance (OR = 1.06, P = .004). Seventy-three percent of pretransplant and 77% of posttransplant patients were classified as having poor sleep quality. Higher body mass index (OR = 1.06, P= .05), sleep medications (OR=0.43, P= .03), and more mood disturbance (OR=1.04, P = .007) were predictive of poor sleep quality in pretransplant patients, whereas higher body mass index (OR=1.07, P= .04) and more anxious mood (OR=1.28, P = .03) were predictive of poor sleep quality in posttransplant patients.
Conclusion
A very high proportion of both pretransplant and posttransplant patients experience clinically severe fatigue levels. Prospective research is necessary to identify causal mechanisms of these disorders and to evaluate strategies to reduce fatigue severity and improve sleep quality.
Details
- Title: Subtitle
- Fatigue and Sleep Quality before and after Liver Transplantation
- Creators
- James R Rodrigue - Beth Israel Deaconess Medical Center, Boston, Massachusetts (JRR, DWH, MC), University of Florida, Gainesville (DRN), University of Iowa, Iowa City (AIR)David R Nelson - Beth Israel Deaconess Medical Center, Boston, Massachusetts (JRR, DWH, MC), University of Florida, Gainesville (DRN), University of Iowa, Iowa City (AIR)Alan I Reed - Beth Israel Deaconess Medical Center, Boston, Massachusetts (JRR, DWH, MC), University of Florida, Gainesville (DRN), University of Iowa, Iowa City (AIR)Douglas W Hanto - Beth Israel Deaconess Medical Center, Boston, Massachusetts (JRR, DWH, MC), University of Florida, Gainesville (DRN), University of Iowa, Iowa City (AIR)Michael Curry - Beth Israel Deaconess Medical Center, Boston, Massachusetts (JRR, DWH, MC), University of Florida, Gainesville (DRN), University of Iowa, Iowa City (AIR)
- Resource Type
- Journal article
- Publication Details
- Progress in transplantation (Aliso Viejo, Calif.), Vol.20(3), pp.221-233
- Publisher
- SAGE Publications; Los Angeles, CA
- DOI
- 10.1177/152692481002000305
- PMID
- 20929106
- ISSN
- 1526-9248
- eISSN
- 2164-6708
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Accounting; Surgery
- Record Identifier
- 9984051554602771
Metrics
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