Journal article
Fatigue in patients with Behcet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity
International journal of rheumatic diseases, Vol.21(12), pp.2139-2145
12/01/2018
DOI: 10.1111/1756-185X.12839
PMID: 26913703
Abstract
Objectives Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behcet's syndrome (BS) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods This is a cross-sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Short form-36 (SF-36), Hospital Anxiety and Depression (HADS) scale and Health Assessment Questionnaire (HAQ). Disease activity among BS patients was assessed using the Behcet Syndrome Activity Scale (BSAS) and the physician's global assessment (PGA). Results BS patients had significantly higher MAF, HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores than the healthy controls (P < 0.001). Both the physical and mental components of the SF-36 scale were impaired in BS patients (P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety (P = 0.0001). MAF scores showed positive correlations with HADS-A, HADS-D, HAQ scores and negative correlations with SF-36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF-36 physical and mental scores, HAQ, HADS-A, HADS-D and BSAS scores (P < 0.05). Decreases in SF-36 physical and mental scores were significant predictive factors for high MAF score in healthy controls (P < 0.05). Conclusions Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.
Details
- Title: Subtitle
- Fatigue in patients with Behcet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity
- Creators
- Birkan Ilhan - Marmara UniversityMeryem Can - Fatih Sultan Mehmet Eğitim Ve Araştırma HastanesiFatma Alibaz-Oner - Marmara UniversitySibel Yilmaz-Oner - Marmara UniversityOzge Polat-Korkmaz - Marmara UniversityGulsen Ozen - Marmara UniversityGonca Mumcu - Marmara UniversityHilal Maradit Kremers - Mayo Clin, Dept Epidemiol, Rochester, MN USAHaner Direskeneli - Marmara University
- Resource Type
- Journal article
- Publication Details
- International journal of rheumatic diseases, Vol.21(12), pp.2139-2145
- Publisher
- Wiley
- DOI
- 10.1111/1756-185X.12839
- PMID
- 26913703
- ISSN
- 1756-1841
- eISSN
- 1756-185X
- Number of pages
- 7
- Language
- English
- Date published
- 12/01/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702939302771
Metrics
4 Record Views