Fatiguing exercise enhances hyperalgesia to muscle inflammation

Kathleen A Sluka; Lynn A Rasmussen

doi:10.1016/j.pain.2009.07.001

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Fatiguing exercise enhances hyperalgesia to muscle inflammation

Journal article

Open access

Peer reviewed

Fatiguing exercise enhances hyperalgesia to muscle inflammation

Kathleen A Sluka and Lynn A Rasmussen

Pain (Amsterdam), Vol.148(2), pp.188-197

02/2010

DOI: 10.1016/j.pain.2009.07.001

PMCID: PMC2815159

PMID: 19632780

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https://www.ncbi.nlm.nih.gov/pmc/articles/2815159View

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Abstract

Since many people with chronic fatigue present with pain and many people with chronic pain present with fatigue, we tested if fatigue would enhance the response to pain in male and female mice. We further tested for the activation of brainstem nuclei by the fatigue task using c-fos as a marker. Fatigue was induced by having mice spontaneously run in running wheel for 2h. Carrageenan (0.03%) was injected into the gastrocnemius muscle either 2h before or 2h after the fatigue task. The mechanical sensitivity of the paw (von Frey filaments), muscle (tweezers), grip force and running wheel activity was assessed before and 24h after injection of carrageenan. Both male and female mice that performed the fatigue task, either before or after intramuscular injection of carrageenan, showed an enhanced mechanical sensitivity of the paw, but not the muscle. Ovariectomized mice showed a similar response to male mice. There was a decrease in running wheel activity after carrageenan injection, but no change in grip force suggesting that mice had no deficit in motor performance induced by the carrageenan. C-fos expression was observed in the nucleus raphe pallidus, obscurus, and magnus after the fatigue task suggesting an increased activity in the raphe nuclei in response to the fatigue task. Therefore, widespread hyperalgesia is enhanced by the fatigue response but not hyperalgesia at the site of insult. We suggest that this effect is sex-dependent and involves mechanisms in the brainstem to result in an enhanced hyperalgesia.

Inflammation - chemically induced

Inflammation - pathology

Pain Threshold - physiology

Mice, Inbred C57BL

Physical Conditioning, Animal - methods

Proto-Oncogene Proteins c-fos - metabolism

Male

Muscle, Skeletal - metabolism

Ovariectomy - methods

Inflammation - complications

Pain Measurement - methods

Animals

Analysis of Variance

Muscle, Skeletal - physiopathology

Hyperalgesia - etiology

Female

Mice

Carrageenan

Muscle, Skeletal - pathology

Muscle Fatigue - physiology

Disease Models, Animal

Muscle Strength - physiology

Details

Title: Subtitle: Fatiguing exercise enhances hyperalgesia to muscle inflammation
Creators: Kathleen A Sluka - Physical Therapy and Rehabilitation Science Graduate Program, Pain Research Program, University of Iowa, Iowa City, IA 52241, USA. kathleen-sluka@uiowa.edu
Lynn A Rasmussen
Resource Type: Journal article
Publication Details: Pain (Amsterdam), Vol.148(2), pp.188-197
DOI: 10.1016/j.pain.2009.07.001
PMID: 19632780
PMCID: PMC2815159
NLM abbreviation: Pain
ISSN: 0304-3959
eISSN: 1872-6623
Publisher: United States
Grant note: AR053509 / NIAMS NIH HHS R01 AR053509-03 / NIAMS NIH HHS R01 AR052316-03 / NIAMS NIH HHS R01 AR052316 / NIAMS NIH HHS R01 AR052316-01A1 / NIAMS NIH HHS R01 AR052316-02 / NIAMS NIH HHS R01 AR053509 / NIAMS NIH HHS R01 AR052316-04 / NIAMS NIH HHS AR052316 / NIAMS NIH HHS R01 AR053509-01A1 / NIAMS NIH HHS R01 AR053509-02 / NIAMS NIH HHS
Language: English
Date published: 02/2010
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984040014702771

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