Fatty acid consumption and risk of fracture in the Women's Health Initiative

Tonya S Orchard; Jane A Cauley; Gail C Frank; Marian L Neuhouser; Jennifer G Robinson; Linda Snetselaar; Fran Tylavsky; Jean Wactawski-Wende; Alicia M Young; Bo Lu; Rebecca D Jackson

doi:10.3945/ajcn.2010.29955

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$Fatty acid consumption and risk of fracture in the Women's Health Initiative$

Journal article

Open access

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Fatty acid consumption and risk of fracture in the Women's Health Initiative

Tonya S Orchard, Jane A Cauley, Gail C Frank, Marian L Neuhouser, Jennifer G Robinson, Linda Snetselaar, Fran Tylavsky, Jean Wactawski-Wende, Alicia M Young, Bo Lu, …

The American journal of clinical nutrition, Vol.92(6), pp.1452-1460

12/2010

DOI: 10.3945/ajcn.2010.29955

PMCID: PMC2980969

PMID: 20980487

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Abstract

Fatty acids (FAs) may be important dietary components that modulate osteoporotic fracture risk. The objective was to examine FA intake in relation to osteoporotic fractures. The participants were postmenopausal women enrolled in the Women's Health Initiative (n = 137,486). Total fractures were identified by self-report; hip fractures were confirmed by medical record review. FA intake was estimated from baseline food-frequency questionnaires and standardized to total caloric intake. No data on omega-3 (n-3) FA supplements were available. Cox proportional hazard models were constructed to estimate risk of fracture. Higher saturated FA consumption was associated with higher hip fracture risk [quartile 4 multivariate-adjusted hazard ratio (HR): 1.31; 95% CI: 1.11, 1.55; P for trend = 0.001]. Lower total fracture risk was associated with a higher monounsaturated FA intake (quartile 3 HR: 0.94; 95% CI: 0.89, 0.98; P for trend = 0.050) and polyunsaturated FA intake (quartile 4 HR: 0.95; 95% CI: 0.90, 0.99; P for trend = 0.019). Unexpectedly, higher consumption of marine n-3 FAs was associated with greater total fracture risk (quartile 4 HR: 1.07; 95% CI: 1.02, 1.12; P for trend = 0.010), whereas a higher n-6 FA intake was associated with a lower total fracture risk (quartile 4 HR: 0.94; 95% CI: 0.89, 0.98; P for trend 0.009). These results suggest that saturated FA intake may significantly increase hip fracture risk, whereas monounsaturated and polyunsaturated FA intakes may decrease total fracture risk. In postmenopausal women with a low intake of marine n-3 FAs, a higher intake of n-6 FAs may modestly decrease total fracture risk. This trial was registered at clinicaltrials.gov as NCT00000611.

Fatty Acids - adverse effects

Dietary Fats - adverse effects

Fatty Acids, Monounsaturated - pharmacology

Humans

Middle Aged

Risk Factors

Self Report

Osteoporosis, Postmenopausal - complications

Proportional Hazards Models

Fish Oils - adverse effects

Hip

Fatty Acids, Omega-6 - pharmacology

Fractures, Bone - etiology

Fatty Acids, Omega-3 - pharmacology

Dietary Fats - administration & dosage

Female

Aged

Fractures, Bone - prevention & control

Fatty Acids - pharmacology

Details

Title: Subtitle: Fatty acid consumption and risk of fracture in the Women's Health Initiative
Creators: Tonya S Orchard - Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA
Jane A Cauley
Gail C Frank
Marian L Neuhouser
Jennifer G Robinson
Linda Snetselaar
Fran Tylavsky
Jean Wactawski-Wende
Alicia M Young
Bo Lu - The Ohio State University
Rebecca D Jackson
Resource Type: Journal article
Publication Details: The American journal of clinical nutrition, Vol.92(6), pp.1452-1460
DOI: 10.3945/ajcn.2010.29955
PMID: 20980487
PMCID: PMC2980969
NLM abbreviation: Am J Clin Nutr
ISSN: 0002-9165
eISSN: 1938-3207
Publisher: United States
Grant note: UL1RR025755 / NCRR NIH HHS N01WH32122 / WHI NIH HHS N01WH32100-2 / WHI NIH HHS UL1 RR025755 / NCRR NIH HHS N01WH32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32118 / WHI NIH HHS TL1RR025753 / NCRR NIH HHS N01WH32105-6 / WHI NIH HHS
Language: English
Date published: 12/2010
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995019902771

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