Journal article
Fear Conditioning Increases NREM Sleep
Behavioral neuroscience, Vol.121(2), pp.310-323
04/2007
DOI: 10.1037/0735-7044.121.2.310
PMCID: PMC2947315
PMID: 17469920
Abstract
To understand the role that sleep may play in memory storage, the authors investigated how fear conditioning affects sleep–wake states by performing electroencephalographic (EEG) and electromyographic recordings of C57BL/6J mice receiving fear conditioning, exposure to conditioning stimuli, or immediate shock treatment. This experimental design allowed us to examine the effects of associative learning, presentation of the conditioning stimuli, and presentation of the unconditioned stimuli on sleep–wake states. During the 24 hr after training, fear-conditioned mice had approximately 1 hr more of nonrapid-eye-movement (NREM) sleep and less wakefulness than mice receiving exposure to conditioning stimuli or immediate shock treatment. Mice receiving conditioning stimuli had more delta power during NREM sleep, whereas mice receiving fear conditioning had less theta power during rapid-eye-movement sleep. These results demonstrate that a single trial of fear conditioning alters sleep–wake states and EEG oscillations over a 24-hr period, supporting the idea that sleep is modified by experience and that such changes in sleep–wake states and EEG oscillations may play a role in memory consolidation.
Details
- Title: Subtitle
- Fear Conditioning Increases NREM Sleep
- Creators
- Kevin Hellman - Neuroscience Graduate Group, University of Pennsylvania;. The Department of Neurobiology, Pharmacology, and Physiology, University of ChicagoTed Abel - Department of Biology, University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.121(2), pp.310-323
- DOI
- 10.1037/0735-7044.121.2.310
- PMID
- 17469920
- PMCID
- PMC2947315
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Grant note
- name: National Institute of Aging, award: AG-18199; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: MH-60244, MH-64329; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HL-60287; DOI: 10.13039/100001391, name: Whitehall Foundation; name: John Merck Foundation; DOI: 10.13039/100000008, name: David and Lucile Packard Foundation
- Language
- English
- Date published
- 04/2007
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065836102771
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