Journal article
Fear Conditioning in Inbred Mouse Strains: An Analysis of the Time Course of Memory
Behavioral neuroscience, Vol.115(4), pp.951-956
08/2001
DOI: 10.1037/0735-7044.115.4.951
PMID: 11508735
Abstract
Three mouse strains were examined for short- and long-term memory for Pavlovian fear conditioning measured 1 hr and 24 hr after conditioning. Both DBA/2J and CBA/J mice exhibit reduced long-term memory for contextual fear conditioning compared with C57BL/6J mice. In cued fear conditioning, however, DBA/2J mice show reduced short- and long-term memory compared with C57BL/6J mice, whereas CBA/J mice exhibit reductions only in short-term memory. These results underscore the importance of examining the time course of memory retention, and they suggest that inbred mouse strains may provide a diversity of phenotypes. The results also suggest that the processes of short- and long-term memory storage as well as contextual and cued fear conditioning are dissociable and are mediated by genetically distinct neurobiological mechanisms.
Details
- Title: Subtitle
- Fear Conditioning in Inbred Mouse Strains: An Analysis of the Time Course of Memory
- Creators
- Ting Nie - Department of Biology, University of PennsylvaniaTed Abel - Department of Biology, University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.115(4), pp.951-956
- Publisher
- American Psychological Association
- DOI
- 10.1037/0735-7044.115.4.951
- PMID
- 11508735
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Language
- English
- Date published
- 08/2001
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065733202771
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