Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial

Kendra Kamp; Linda Yoo; Tanvi Kale; Xiaoyu Zhang; Caeli Malloy; Ihsan Kahveci; Rachael Cordova; Isabela Hernandez; Chi Shan Tsai; Tiffany D. Pan; Kindra Clark-Snustad; Scott Lee; Rona L. Levy; Laurie Keefer; Margaret Heitkemper

doi:10.1007/s10620-026-10111-8

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Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial

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Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial

Kendra Kamp, Linda Yoo, Tanvi Kale, Xiaoyu Zhang, Caeli Malloy, Ihsan Kahveci, Rachael Cordova, Isabela Hernandez, Chi Shan Tsai, Tiffany D. Pan, …

Digestive diseases and sciences

07/18/2026

DOI: 10.1007/s10620-026-10111-8

PMID: 42470576

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Abstract

Purpose Individuals with inflammatory bowel disease experience persistent symptoms and disease challenges which may not be solved with medical management. Self-management interventions may support patients, but their feasibility, acceptability, and preliminary effectiveness should be evaluated prior to large-scale testing.Methods We conducted a pilot randomized controlled trial with 2:1 allocation of a nurse-delivered, self-management program to usual care. Adults with a healthcare provider diagnosis of ulcerative colitis or Crohn's disease, aged 18-75 years, currently reporting at least two symptoms were recruited. The self-management program included eight online modules plus weekly phone check-ins with a registered nurse. Feasibility and acceptability were measured using surveys and interviews. Secondary outcomes included patient activation, self-regulation, self-efficacy, functional impairment, quality of life, symptoms, and fecal calprotectin. Linear mixed models estimated the differences in change scores between groups from baseline to 3- and 6-month follow-up.Results Fifty-five participants were randomized (n = 36 self-management, n = 19 usual care). Participants were on average 39.0 years old (range: 20-73), 76.4% women, and 80% Crohn's disease. The self-management program demonstrated high satisfaction (91.1/100), feasibility (4.34/5), and acceptability (4.28/5). Compared with usual care, the self-management program produced the largest improvement in functional impairment (mean change - 15.1 [95% CI - 23.3, - 6.8], with additional improvements in patient activation (10.3 [2.8, 17.9]), self-regulation (4.1 [1.1, 7.1]), and quality of life (4.6 [0.3, 8.9]). Symptom severity and fecal calprotectin were largely unchanged. Qualitative feedback emphasized the value of regular nurse check-ins, accountability, and applicability of the program beyond disease-specific concerns.Conclusions A nurse-delivered self-management program was feasible, acceptable, and led to meaningful changes in key intervention targets for inflammatory bowel disease management. High engagement supports potential for future testing in a fully powered trial and eventual integration into routine care.

Gastroenterology & Hepatology

Life Sciences & Biomedicine

Science & Technology

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Title: Subtitle: Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial
Creators: Kendra Kamp - Neurobehavioral Systems
Linda Yoo - Neurobehavioral Systems
Tanvi Kale - Neurobehavioral Systems
Xiaoyu Zhang - Neurobehavioral Systems
Caeli Malloy - Neurobehavioral Systems
Ihsan Kahveci - University of Washington
Rachael Cordova - Valley Health System
Isabela Hernandez - University of Miami
Chi Shan Tsai - University of Washington
Tiffany D. Pan - University of Washington
Kindra Clark-Snustad - University of Washington
Scott Lee - University of Washington
Rona L. Levy - University of Washington
Laurie Keefer - Mount Sinai Hospital
Margaret Heitkemper - Neurobehavioral Systems
Resource Type: Journal article
Publication Details: Digestive diseases and sciences
DOI: 10.1007/s10620-026-10111-8
PMID: 42470576
NLM abbreviation: Dig Dis Sci
ISSN: 0163-2116
eISSN: 1573-2568
Publisher: Springer Nature
Number of pages: 12
Grant note: P2C HD042828 / Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1 TR002319 / Institute of Clinical and Translational Sciences K23 NR020044; T32016913 / National Institute of Nursing Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR)
Language: English
Date published: 07/18/2026
Academic Unit: Nursing
Record Identifier: 9985219861802771

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