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Feasibility and Accuracy of the ASERT Digital Questionnaire in Mood Tracking for a Longitudinal Research Study on Bipolar Disorder
Journal article   Open access   Peer reviewed

Feasibility and Accuracy of the ASERT Digital Questionnaire in Mood Tracking for a Longitudinal Research Study on Bipolar Disorder

Isaac Lynch, Gail I.S. Harmata, Ercole John Barsotti, Jess G. Fiedorowicz, Aislinn J. Williams, Cari Linkenmeyer, Sarah Smith, Spencer Smith, Jenny Gringer Richards, Jeffrey D. Long, …
Journal of mood and anxiety disorders, Vol.12, 100145
12/2025
DOI: 10.1016/j.xjmad.2025.100145
PMCID: PMC12445695
PMID: 40979181
url
https://doi.org/10.1016/j.xjmad.2025.100145View
Published (Version of record) Open Access

Abstract

It is challenging for bipolar disorder (BD) studies to capture multiple mood states within a participant at in-person visits. Mood tracking could aid scheduling, but evaluation is usually done using clinical assessments inconvenient for participants to undergo often. However, frequent assessments are necessary to capture dynamic mood changes typical of BD. The Aktibipo Self-Rating Questionnaire (ASERT) is a simple, self-report mood survey. We examined the utility of collecting the ASERT weekly to assess mood changes and schedule follow-up visits. Sixty-one participants with BD completed the ASERT and were administered the Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) during a baseline visit. Participants were then sent weekly text messages with an ASERT survey link. If participants exhibited at least a 5-point (later 8-point) change from baseline on either the mania or depression subscale, they were called and administered the MADRS or YMRS. A 10-point change on either phone-delivered clinical scale prompted a follow-up visit. Associations between ASERT subscales and clinical scales were evaluated using Spearman’s correlation and robust regression. Mean completion rate was 94.8% and median completion time was 67seconds. The ASERT depression and mania subscales correlated with the MADRS and YMRS at baseline and all follow-up time points. Our screening method aided scheduling, with 15 of 19 participants exhibiting a 10-point change or greater on the MADRS and/or YMRS at Visit 2. The ASERT can be feasibly deployed to track mood and can help schedule follow-up assessments in BD longitudinal studies. [Display omitted] •Obtaining in-person data across mood states in bipolar disorder is difficult.•We demonstrate a feasible way to track mood to schedule follow-up visits.•We used the Aktibipo Self-Rating Questionnaire (ASERT) to track mood.•The ASERT corresponded to clinical scales at all time points tested.•Change in the weekly ASERT from baseline predicted depression change at follow-up.
 bipolar disorder depression longitudinal studies mania mood tracking

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