Journal article
Feasibility and Safety of Intrathoracic Biopsy and Repeat Biopsy for Evaluation of Programmed Cell Death Ligand-1 Expression for Immunotherapy in Non-Small Cell Lung Cancer
Radiology, Vol.287(1), pp.326-332
04/2018
DOI: 10.1148/radiol.2017170347
PMCID: PMC6276060
PMID: 29232184
Abstract
Purpose To determine feasibility and safety of biopsy and repeat biopsy for assessment of programmed cell death ligand-1 (PD-L1) status. Materials and Methods This retrospective analysis reviewed 101 patients who underwent transthoracic core needle biopsy for the KEYNOTE-001 (MK-3475) clinical trial of pembrolizumab, an antiprogrammed cell death-1 therapy for non-small cell lung cancer, from May 2012 to September 2014. Sixty-one male patients (mean age, 66.1 years; range 36-83 years) and 40 female patients (mean age, 66.8 years; age range, 36-90 years) were included. Data collected included population characteristics, treatment history, target location, size, and depth from pleura. Adequacy of the tissue sample for diagnostic testing and rates of biopsy-related complications were assessed. Statistical analysis was performed by using univariate and multivariate generalized linear models to determine significant risk factors for biopsy complications. Results A total of 110 intrathoracic biopsies were performed, and 101 (91.8%) were performed as repeat biopsies subsequent to a previous percutaneous or bronchoscopic biopsy or previous surgical biopsy or resection. More than 84.5% (93 of 110) of biopsies were performed in patients who had undergone previous local or systemic therapy. Specimens were adequate for evaluation of PD-L1 expression in 96.4% of biopsies. Procedure-related complications occurred in 28 biopsies (25.4%); pneumothorax was most common (22.7%). Overall mean number of core needle biopsy samples obtained was 7.9 samples. Conclusion Image-guided transthoracic core needle biopsy is an effective method for obtaining tissue for PD-L1 expression analysis.
RSNA, 2017.
Details
- Title: Subtitle
- Feasibility and Safety of Intrathoracic Biopsy and Repeat Biopsy for Evaluation of Programmed Cell Death Ligand-1 Expression for Immunotherapy in Non-Small Cell Lung Cancer
- Creators
- Emily B Tsai - University of California, Los AngelesKelsey Pomykala - University of California, Los AngelesKathleen Ruchalski - University of California, Los AngelesScott Genshaft - University of California, Los AngelesFereidoun Abtin - University of California, Los AngelesAntonio Gutierrez - University of California, Los AngelesHyun J Kim - University of California, Los AngelesAlice Li - University of California, Los AngelesCarlos Adame - University of California, Los AngelesAshkan Jalalian - University of California, Los AngelesBrian Wolf - University of California, Los AngelesEdward B Garon - University of California, Los AngelesJonathan W Goldman - University of California, Los AngelesRobert Suh - University of California, Los Angeles
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.287(1), pp.326-332
- DOI
- 10.1148/radiol.2017170347
- PMID
- 29232184
- PMCID
- PMC6276060
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Grant note
- R01 CA208403 / NCI NIH HHS P30 CA016042 / NCI NIH HHS
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294950002771
Metrics
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