Journal article
Feasibility and optimization of 19 F MRI on a clinical 3T with a large field-of-view torso coil
Physics in medicine & biology, Vol.69(12), 125002
06/04/2024
DOI: 10.1088/1361-6560/ad4d50
PMCID: PMC11149172
PMID: 38759675
Appears in UI Libraries Support Open Access
Abstract
The purpose of this work is to: 1) demonstrate fluorine-19 (19F) MRI on a 3T clinical system with a large field-of-view (FOV) multi-channel torso coil 2) demonstrate an example parameter selection optimization for a 19F agent to maximize the SNR-efficiency for SPGR, bSSFP, and phase-cycled bSSFP (bSSFP-C), and 3) validate detection feasibility in ex vivo tissues. Methods: Measurements were conducted on a 3.0T Discovery MR750w MRI (GE Healthcare, USA) with an 8-channel 1H/19F torso coil (MRI Tools, Germany). Numerical simulations were conducted for perfluoropolyether (PFPE) to determine the theoretical parameters to maximize SNR-efficiency for the sequences. Theoretical parameters were experimentally verified, and the sensitivity of the sequences was compared with a 10-minute acquisition time with a 3.125x3.125x3mm3 in-plane resolution. Feasibility of a bSSFP-C was also demonstrated in phantom and ex vivo tissues. Results: Flip angles (FA) of 12 and 64 degrees maximized the signal for SPGR and bSSFP, and validation of optimal FA and receiver bandwidth showed close agreement with numerical simulations. Sensitivities of 2.47, 5.81, and 4.44 ms^(-0.5) mM^(-1) and empirical detection limits of 20.3, 1.5, and 6.2 mM were achieved for SPGR, bSSFP, and bSSFP-C, respectively. bSSFP and bSSFP-C achieved 1.8-fold greater sensitivity over SPGR (p<0.01). Conclusion: bSSFP-C was able to improve sensitivity relative to simple SPGR and reduce both bSSFP banding effects and imaging time. The sequence was used to demonstrate the feasibility of 19F MRI at clinical FOVs and field strengths within ex-vivo tissues.
Details
- Title: Subtitle
- Feasibility and optimization of 19 F MRI on a clinical 3T with a large field-of-view torso coil
- Creators
- Lawrence Lechuga - University of Wisconsin–MadisonMonica M Cho - University of Wisconsin–MadisonDavid M Vail - University of Wisconsin–MadisonChristian M Capitini - University of Wisconsin–MadisonSean B Fain - University of IowaPaul Begovatz - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.69(12), 125002
- DOI
- 10.1088/1361-6560/ad4d50
- PMID
- 38759675
- PMCID
- PMC11149172
- NLM abbreviation
- Phys Med Biol
- eISSN
- 1361-6560
- Publisher
- IOP Publishing
- Language
- English
- Electronic publication date
- 05/17/2024
- Date published
- 06/04/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology
- Record Identifier
- 9984628237602771
Metrics
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