Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial

Richard S E Keefe; Sophia Vinogradov; Alice Medalia; Peter F Buckley; Stanley N Caroff; Deepak C D'Souza; Phillip D Harvey; Karen A Graham; Robert M Hamer; Del D Miller; Stephen M Marder; Stephen J Olson; Jayendra K Patel; Dawn Velligan; Trina M Walker; Adam J Haim; T Scott Stroup

doi:10.4088/jcp.11m07100

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Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial

Journal article

Peer reviewed

Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial

Richard S E Keefe, Sophia Vinogradov, Alice Medalia, Peter F Buckley, Stanley N Caroff, Deepak C D'Souza, Phillip D Harvey, Karen A Graham, Robert M Hamer, Del D Miller, …

The journal of clinical psychiatry, Vol.73(7), pp.1016-1022

07/2012

DOI: 10.4088/jcp.11m07100

PMCID: PMC3746329

PMID: 22687548

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https://www.ncbi.nlm.nih.gov/pmc/articles/3746329View

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Abstract

The true benefit of pharmacologic intervention to improve cognition in schizophrenia may not be evident without regular cognitive enrichment. Clinical trials assessing the neurocognitive effects of new medications may require engagement in cognitive remediation exercises to stimulate the benefit potential. However, the feasibility of large-scale multisite studies using cognitive remediation at clinical trials sites has not been established.

Feasibility Studies

Psychotic Disorders - diagnosis

Schizophrenia - therapy

Double-Blind Method

Evidence-Based Practice

Humans

Middle Aged

Psychotic Disorders - psychology

Male

Treatment Outcome

Schizophrenic Psychology

Psychotic Disorders - therapy

Neuropsychological Tests

Cognition Disorders - diagnosis

Pilot Projects

Remedial Teaching

Computer-Assisted Instruction

Schizophrenia - diagnosis

Adult

Female

Cognition Disorders - therapy

Inservice Training

Cognition Disorders - psychology

Details

Title: Subtitle: Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial
Creators: Richard S E Keefe - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. richard.keefe@duke.edu
Sophia Vinogradov
Alice Medalia
Peter F Buckley
Stanley N Caroff
Deepak C D'Souza
Phillip D Harvey
Karen A Graham
Robert M Hamer
Del D Miller
Stephen M Marder
Stephen J Olson
Jayendra K Patel
Dawn Velligan
Trina M Walker
Adam J Haim
T Scott Stroup
Resource Type: Journal article
Publication Details: The journal of clinical psychiatry, Vol.73(7), pp.1016-1022
DOI: 10.4088/jcp.11m07100
PMID: 22687548
PMCID: PMC3746329
NLM abbreviation: J Clin Psychiatry
ISSN: 0160-6689
eISSN: 1555-2101
Publisher: United States
Grant note: N01MH90001 / NIMH NIH HHS N01 MH900001 / NIMH NIH HHS
Language: English
Date published: 07/2012
Academic Unit: Psychiatry
Record Identifier: 9984003935402771

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