Journal article
Feasibility and safety of AS-3 red blood cells for neonatal transfusions
The Journal of pediatrics, Vol.136(2), pp.215-219
02/01/2000
DOI: 10.1016/S0022-3476(00)70104-1
PMID: 10657828
Abstract
Objectives: Most extremely low birth weight (<1 kg) infants receive red blood cell (RBC) transfusions. RBCs stored up to 42 days can be transfused safely in small volumes to preterm infants; however, because the formulation of RBC anticoagulant/preservative solutions differs, clinical studies are required to document the safety of each solution before widespread use. Our goal was to study the feasibility and safety of AS-3 anticoagulant/preservative solution to preterm infants.
Study design: Two clinical studies were conducted in sequence: (1) a randomized trial to compare RBC transfusions given as stored (≤42 days) AS-3 RBCs (11 infants) versus fresh (≤7 days) citrate, phosphate, dextrose, and adenine RBCs (10 infants) and (2) a subsequent evaluation of the safety of stored AS-3 RBCs in 33 additional preterm infants given 120 AS-3 RBC transfusions.
Results: Results of both the randomized study and the subsequent evaluation documented that AS-3 RBCs stored ≤42 days and transfused in small volumes (15 mL/kg) were safe for RBC transfusions of preterm infants. Donor exposure was significantly reduced, clinical transfusion reactions were rare, and post-transfusion blood hematocrit, pH, and plasma Na, K, Ca, lactate, and glucose measurements were similar when AS-3 and citrate, phosphate, dextrose, and adenine RBC transfusions were compared.
Conclusions: AS-3 RBCs can be used safely for small-volume RBC transfusions for preterm infants. (J Pediatr 2000;136:215-9)
Details
- Title: Subtitle
- Feasibility and safety of AS-3 red blood cells for neonatal transfusions
- Creators
- Ronald G. Strauss - University of IowaLeon F. Burmeister - University of IowaKaren Johnson - University of IowaGretchen Cress - University of IowaDelores Cordle - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.136(2), pp.215-219
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0022-3476(00)70104-1
- PMID
- 10657828
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 02/01/2000
- Academic Unit
- Stead Family Department of Pediatrics; Pathology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984622747502771
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