Journal article
Fecal microbiota transplantation to patients with refractory very early onset ulcerative colitis
Pediatric gastroenterology, hepatology & nutrition, Vol.21(4), pp.355-360
10/01/2018
DOI: 10.5223/pghn.2018.21.4.355
PMID: 30345252
Abstract
Recently, fecal microbiota transplantation (FMT) has been attracting attention as a possible medical treatment of ulcerative colitis (UC). A randomized controlled trial of FMT for children with UC is currently underway. Therapeutic effects of FMT for adults with UC remain controversial. We report two cases of early-onset UC in children. A patient was diagnosed with UC at age 1-year 9-month and underwent FMT at age 2-year 3-month. He attained clinical remission for three weeks after FMT, but then relapsed at four weeks, ultimately undergoing a total colectomy. Another child was diagnosed with UC at 2-year 10-month and she underwent FMT at age 5 years. She has remained in clinical remission following FMT for 24 months and her UC has been maintained without complications with tacrolimus and azathioprine. We report that FMT for early-onset UC appears to be safe and potentially effective.
Details
- Title: Subtitle
- Fecal microbiota transplantation to patients with refractory very early onset ulcerative colitis
- Creators
- Toshifumi Yodoshi - Jikei University School of MedicineThomas L. Hurt - Mary Bridge Children's Health Center
- Resource Type
- Journal article
- Publication Details
- Pediatric gastroenterology, hepatology & nutrition, Vol.21(4), pp.355-360
- DOI
- 10.5223/pghn.2018.21.4.355
- PMID
- 30345252
- NLM abbreviation
- Pediatr Gastroenterol Hepatol Nutr
- ISSN
- 2234-8646
- eISSN
- 2234-8840
- Number of pages
- 6
- Language
- English
- Date published
- 10/01/2018
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214107202771
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