Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases

Casey G. Turner; Anna E. Stanhewicz; Brett J. Wong

doi:10.3389/fphys.2020.596507

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Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases

Journal article

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Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases

Casey G. Turner, Anna E. Stanhewicz and Brett J. Wong

Frontiers in physiology, Vol.11, pp.596507-596507

10/27/2020

DOI: 10.3389/fphys.2020.596507

PMCID: PMC7652897

PMID: 33192613

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Abstract

Many studies of vascular function limit the testing of premenopausal female participants to periods when female sex hormones, either endogenous or exogenous, are at their lowest concentration. This practice, when not part of the specific research question, may limit data surrounding the predominant physiological state of premenopausal females and pose a threat to external validity. In this Perspective, we briefly review the literature on the effect of female sex hormones on vascular function and discuss when limiting experimental testing to a certain phase of the menstrual cycle (MC) or oral contraceptive (OC) use may be appropriate. The goal of this Perspective is to open a dialog that may enhance data validity and the overall understanding of vascular function in premenopausal females.

Life Sciences & Biomedicine

Physiology

Science & Technology

Details

Title: Subtitle: Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases
Creators: Casey G. Turner - Georgia State University
Anna E. Stanhewicz - University of Iowa
Brett J. Wong - Georgia State University
Resource Type: Journal article
Publication Details: Frontiers in physiology, Vol.11, pp.596507-596507
DOI: 10.3389/fphys.2020.596507
PMID: 33192613
PMCID: PMC7652897
NLM abbreviation: Front Physiol
ISSN: 1664-042X
eISSN: 1664-042X
Publisher: Frontiers Media Sa
Number of pages: 6
Grant note: R01-HL141205-03; R00 HL138133-03 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 10/27/2020
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984259402502771

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