Journal article
Femoral Neck External Size But Not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause
Journal of bone and mineral research, Vol.32(6), pp.1218-1228
06/2017
DOI: 10.1002/jbmr.3082
PMCID: PMC5466474
PMID: 28084657
Abstract
The impact of adult bone traits on changes in bone structure and mass during aging is not well understood. Having shown that intracortical remodeling correlates with external size of adult long bones led us to hypothesize that age-related changes in bone traits also depend on external bone size. We analyzed hip dual-energy X-ray absorptiometry images acquired longitudinally over 14 years for 198 midlife women transitioning through menopause. The 14-year change in bone mineral content (BMC, R-2 = 0.03, p = 0.015) and bone area (R-2 = 0.13, p = 0.001), but not areal bone mineral density (aBMD, R-2 = 0.00, p = 0.931) correlated negatively with baseline femoral neck external size, adjusted for body size using the residuals from a linear regression between baseline bone area and height. The dependence of the 14-year changes in BMC and bone area on baseline bone area remained significant after adjusting for race/ ethnicity, postmenopausal hormone use, the 14-year change in weight, and baseline aBMD, weight, height, and age. Women were sorted into tertiles using the baseline bone area-height residuals. The 14-year change in BMC (p = 0.009) and bone area (p = 0.001) but not aBMD (p = 0.788) differed across the tertiles. This suggested that women showed similar changes in aBMD for different structural and biological reasons: women with narrow femoral necks showed smaller changes in BMC but greater increases in bone area compared to women with wide femoral necks who showed greater losses in BMC but without large compensatory increases in bone area. Thi finding is opposite to expectations that periosteal expansion acts to mechanically offset bone loss. Thus, changes in femoral neck structure and mass during menopause vary widely among women and are predicted by baseline external bone size but not aBMD. How these different structural and mass changes affect individual strength-decline trajectories remains to be determined. (C) 2017 American Society for Bone and Mineral Research.
Details
- Title: Subtitle
- Femoral Neck External Size But Not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause
- Creators
- Karl J. Jepsen - University of Michigan–Ann ArborAndrew Kozminski - University of Michigan–Ann ArborErin M. R. Bigelow - University of Michigan–Ann ArborStephen H. Schlecht - University of Michigan–Ann ArborRobert W. Goulet - University of Michigan–Ann ArborSioban D. Harlow - University of Michigan–Ann ArborJane A. Cauley - University of PittsburghCarrie Karvonen-Gutierrez - Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
- Resource Type
- Journal article
- Publication Details
- Journal of bone and mineral research, Vol.32(6), pp.1218-1228
- Publisher
- Wiley
- DOI
- 10.1002/jbmr.3082
- PMID
- 28084657
- PMCID
- PMC5466474
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- Number of pages
- 11
- Grant note
- career development award from the University of Michigan Older Americans Independence Center NIH, DHHS, through the National Institute on Aging (NIA) U01AG012546 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) National Institute of Nursing Research (NINR); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) T32DE007057 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) U01NR004061 / NATIONAL INSTITUTE OF NURSING RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) AG026463; AR065424; AG024824-10 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01NR004061; U01AG012505; U01AG012535; U01AG012531; U01AG012539; U01AG012546; U01AG012553; U01AG012554; U01AG012495 / NIH Office of Research on Women's Health (ORWH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30AR069620 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984702943602771
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