Journal article
Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children
Acta anaesthesiologica Scandinavica, Vol.50(9), pp.1161-1164
10/2006
DOI: 10.1111/j.1399-6576.2006.01134.x
PMID: 16987347
Abstract
Background: Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children.
Methods: Eighty children (2–8 years) were enrolled in a randomized, double-blind study. Forty received saline and 40 received 2 μg/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg/kg in both groups. Patients were assistant-ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson’s chi-squared test.
Results: The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; P < 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, P < 0.05).
Conclusions: Intravenous fentanyl in children reduces airway complications caused by desflurane.
Details
- Title: Subtitle
- Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children
- Creators
- J. Lee - Seoul National UniversityY. Oh - Seoul National UniversityC. Kim - Seoul National UniversityS. Kim - Seoul National UniversityH. Park - Seoul National UniversityH. Kim - Seoul National University
- Resource Type
- Journal article
- Publication Details
- Acta anaesthesiologica Scandinavica, Vol.50(9), pp.1161-1164
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1399-6576.2006.01134.x
- PMID
- 16987347
- ISSN
- 0001-5172
- eISSN
- 1399-6576
- Number of pages
- 4
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806500302771
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