Journal article
Ferromagnetic hyperthermia: Functional and histopathologic effects on normal rabbit ocular tissue
International journal of hyperthermia, Vol.13(4), pp.423-436
1997
DOI: 10.3109/02656739709046543
PMID: 9278771
Abstract
Ferromagnetic (FM) hyperthermia has previously been evaluated in a rabbit tumour model of ocular melanoma. To study the effect of focal heating in normal rabbit eyes, FM seeds were implanted into a 14-mm episcleral plaque and heated to operating temperatures of 48 or 54°C. Thermal induction was performed by placing rabbits in a uniform, oscillating (100 kHz) magnetic field operating at 1200 W and an H-field strength of 265A/m. Eyes were heated for 60min with continuous scleral temperature monitoring. Hyperthermic effects were monitored by direct ophthalmic examination, fundus photography, serial electroretinography and histopathology. Intraocular temperatures were mapped with direct fiberoptic thermometry. All treatment effects were confined to the area covered by the episcleral plaque. Direct ophthalmoscopic examination revealed early retinal whitening during heat induction followed by localized exudative retinal detachments, limited to the area of the retinal surface overlying the plaque, that resolved spontaneously. Serial electroretinography was virtually indistinguishable between the 48 and 54°C treatment groups. We noted a minimal alteration in a- and b-wave amplitudes with no changes in implicit times. Histopathology at 3 weeks post-treatment documented chorioretinal scarring overlying the thermal plaque treatment zone. No evidence of haemorrhage, infection, cataract or scleral thinning was noted. This study documents the apparent focal containment of thermal effects with FM heating utilizing operating temperatures as high as 54°C for 60 min, and discloses no evidence of diffuse ocular toxicity.
Details
- Title: Subtitle
- Ferromagnetic hyperthermia: Functional and histopathologic effects on normal rabbit ocular tissue
- Creators
- T. G Murray - 1Department of Ophthalmology and Radiation Oncology, University of Miami, Bascom Palmer Eye Institute, PO Box 016880, Miami, FL, 33101-6880, USAR. A Steeves - 2Department of Ophthalmology and Human Oncology, University of Wisconsin, 600 Highland Avenue, K4/B100, Madison, WI, 53792, USAL Gentry - 2Department of Ophthalmology and Human Oncology, University of Wisconsin, 600 Highland Avenue, K4/B100, Madison, WI, 53792, USAG Bresnick - 2Department of Ophthalmology and Human Oncology, University of Wisconsin, 600 Highland Avenue, K4/B100, Madison, WI, 53792, USAH. C Boldt - 3Department of Ophthalmology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USAW. F Mieler - 4Department of Ophthalmology, Medical College of Wisconsin, The Eye Institute, 8700 West Wisconsin Avenue, Milwaukee, WI, 53226, USAD Tompkins - 2Department of Ophthalmology and Human Oncology, University of Wisconsin, 600 Highland Avenue, K4/B100, Madison, WI, 53792, USA
- Resource Type
- Journal article
- Publication Details
- International journal of hyperthermia, Vol.13(4), pp.423-436
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/02656739709046543
- PMID
- 9278771
- ISSN
- 0265-6736
- eISSN
- 1464-5157
- Language
- English
- Date published
- 1997
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984083830902771
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