Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997

Jennita Reefhuis; Margaret A Honein; Gary M Shaw; Paul A Romitti

doi:10.1542/peds.111.S1.1163

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Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997

Journal article

Peer reviewed

Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997

Jennita Reefhuis, Margaret A Honein, Gary M Shaw and Paul A Romitti

Pediatrics (Evanston), Vol.111(5 Pt 2), pp.1163-1166

05/2003

DOI: 10.1542/peds.111.S1.1163

PMID: 12728131

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Abstract

Craniosynostosis, a malformation caused by premature closure of 1 or more cranial sutures, is a rare birth defect usually of unknown cause; however, it is often associated with advanced maternal age. Because fertility treatments are also associated with increased maternal age, this study investigated the possible association between fertility treatments and craniosynostosis. Data from the Birth Defect Risk Factor Surveillance study were used, which included infants who were delivered from 1993 through 1997 in California, Georgia, and Iowa. Cases were defined as infants who had nonfamilial, nonsyndromic craniosynostosis and were ascertained through existing birth defect surveillance systems. Controls, infants without birth defects, were selected from the same regions and time period. Mothers of 99 case infants and 777 control infants from the 3 study locations participated in this study by completing a telephone interview. Unadjusted analyses showed associations with craniosynostosis for mothers who had used clomiphene citrate (odds ratio[OR]: 3.8; 95% confidence interval [CI]: 1.1-12.3), artificial insemination (OR: 4.2; 95% CI: 0.8-9.4), or assisted reproductive techniques (OR: 4.2; 95% CI: 0.5-27.3). This is the first study that has found associations between fertility treatments and craniosynostosis. However, the numbers are small; therefore, the results should be viewed with caution.

Pregnancy

Craniosynostoses - epidemiology

California - epidemiology

Humans

Male

Case-Control Studies

Craniosynostoses - etiology

Reproductive Techniques, Assisted - adverse effects

Maternal Age

Female

Iowa - epidemiology

Population Surveillance

Infant, Newborn

Georgia - epidemiology

Details

Title: Subtitle: Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997
Creators: Jennita Reefhuis - Epidemiology Program Office and National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. nzr5@cdc.gov
Margaret A Honein
Gary M Shaw
Paul A Romitti
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.111(5 Pt 2), pp.1163-1166
DOI: 10.1542/peds.111.S1.1163
PMID: 12728131
NLM abbreviation: Pediatrics
ISSN: 0031-4005
eISSN: 1098-4275
Publisher: American Academy of Pediatrics; United States
Language: English
Date published: 05/2003
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983996082102771

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