Journal article
Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation
Translational stroke research, Vol.3(Supplement 1), pp.166-173
07/2012
DOI: 10.1007/s12975-012-0172-y
PMCID: PMC3445332
PMID: 23002401
Abstract
Inflammation cell infiltration and cytokine expression are seen in the vascular walls and intervening stroma of resected brain arteriovenous malformation (bAVM) specimens, even in unruptured and previously untreated lesions. Macrophages may play a critical role in bAVM progression to rupture, and could serve as a marker for rupture risk. We assessed feasibility of imaging macrophages within the bAVM nidus using ferumoxytol-enhanced MRI in four patients with already diagnosed bAVMs using iron-sensitive imaging (ISI; T2*-GE-MRI sequence). Patients were imaged at baseline and at either 1 day (n=2) or 5 days (n=2) after infusion of 5mg/kg of ferumoxytol. Residual intravascular ferumoxytol obscured evaluation for uptake in bAVM vascular walls and stroma at the 1-day time point. The two cases imaged at 5 days showed less intravascular tracer but had signal loss in the nidal region consistent with ferumoxytol localization. One case underwent surgical resection; there was prominent vascular wall CD68 staining. Ferumoxytol-enhanced-MRI for assessing bAVM inflammatory cell burden appears feasible and has the potential to be developed as a biomarker to study lesional inflammatory events.
Details
- Title: Subtitle
- Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation
- Creators
- David M Hasan - Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IAMatthew Amans - Department of Radiology, University of California, San Francisco, San Francisco, CATarik Tihan - Department of Pathology, University of California, San Francisco, San Francisco, CAChristopher Hess - Department of Radiology, University of California, San Francisco, San Francisco, CAYi Guo - Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CASoonmee Cha - Department of Radiology, University of California, San Francisco, San Francisco, CAHua Su - Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CAAlastair J Martin - Department of Radiology, University of California, San Francisco, San Francisco, CAMichael T Lawton - Department of Neurological Surgery, University of California, San Francisco, San Francisco, CAEdward A Neuwelt - Departments of Neurological Surgery and Neurology, Oregon Health & Science University, Portland, ORDavid A Saloner - Department of Radiology, University of California, San Francisco, San Francisco, CAWilliam L Young - Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
- Resource Type
- Journal article
- Publication Details
- Translational stroke research, Vol.3(Supplement 1), pp.166-173
- DOI
- 10.1007/s12975-012-0172-y
- PMID
- 23002401
- PMCID
- PMC3445332
- NLM abbreviation
- Transl Stroke Res
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- Grant note
- P01 NS044155 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Language
- English
- Date published
- 07/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040340002771
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