Journal article
Fetal Constraint as a Potential Risk Factor for Craniosynostosis
American journal of medical genetics. Part A, Vol.152A(2), pp.394-400
02/2010
DOI: 10.1002/ajmg.a.33246
PMCID: PMC2815148
PMID: 20101684
Abstract
Non-syndromic craniosynostosis is multifactorial, and fetal head constraint has been hypothesized as one factor thought to play a role. Data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, were used to evaluate associations between 4 selected factors related to fetal constraint and craniosynostosis: plurality (twins or higher), macrosomia (birth weight > 4000 g), post-term gestational age (≥42 weeks), and nulliparity (no previous live births). Case infants (n=675) had craniosynostosis documented either by radiographic evidence or by surgical intervention. Infants with a recognized or strongly suspected single-gene conditions or chromosomal abnormalities were excluded. Control infants (n=5,958) had no major birth defects and were randomly selected from the same population as case infants. Logistic regression was used to estimate odds ratios for the association between these 4 factors and craniosynostosis, while adjusting for several covariates. We found that plurality and nulliparity were associated with a two fold increased risk for metopic craniosynostosis, and macrosomia had almost twice the risk of developing coronal craniosynostosis. Contrary to our hypothesis, prematurity and low birth weight were also associated with craniosynostosis. In conclusion, these 4 constraint-related factors were not found to be associated with craniosynostosis when all suture types were combined, though some types of craniosynostosis were associated with individual constraint-related factors.
Details
- Title: Subtitle
- Fetal Constraint as a Potential Risk Factor for Craniosynostosis
- Creators
- Pedro A Sanchez-Lara - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GASuzan L Carmichael - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GAJohn M Graham - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GAEdward J Lammer - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GAGary M Shaw - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GAChen Ma - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GASonja A Rasmussen - Childrens Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA California Research Division, March of Dimes Foundation, Oakland, CA Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles CA Childrens Hospital Oakland Research Institute, Oakland, CA Stanford University School of Medicine Centers for Disease Control and Prevention, Atlanta, GANational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part A, Vol.152A(2), pp.394-400
- DOI
- 10.1002/ajmg.a.33246
- PMID
- 20101684
- PMCID
- PMC2815148
- NLM abbreviation
- Am J Med Genet A
- ISSN
- 1552-4825
- eISSN
- 1552-4833
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214791702771
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