Journal article
Fibrin films: overlooked hemostatic barriers against microbial infiltration
The Journal of clinical investigation, Vol.128(8), pp.3243-3245
08/01/2018
DOI: 10.1172/JCI121858
PMCID: PMC6063499
PMID: 29939163
Abstract
The hemostatic response to vascular injury culminates in a fibrin clot network that forms an initial barrier to blood loss and also contributes to microbial host defense. Fibrinogen is cleaved by thrombin into fibrin monomers that spontaneously polymerize into protofibrils and form the extensive fiber networks characteristic of blood clots. In this issue of the JCI, Macrae and colleagues characterize an alternative fibrin structure in which fibrinogen and fibrin assemble into a continuous 2D film at the exterior face of the fibrin clot network. Fibrin films connect to the underlying fiber network through tethering fibers and provide a protective barrier to microbial infiltration. These findings shed new light on a previously overlooked mechanism of fibrin assembly at the clot surface and provide a link between hemostasis and innate immunity.
Details
- Title: Subtitle
- Fibrin films: overlooked hemostatic barriers against microbial infiltration
- Creators
- Sean X. Gu - Univ Iowa, Dept Internal Med, Carver Coll Med, C21 GH,200 Hawkins Dr, Iowa City, IA 52242 USASteven R. Lentz - Univ Iowa, Dept Internal Med, Carver Coll Med, C21 GH,200 Hawkins Dr, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.128(8), pp.3243-3245
- Publisher
- Amer Soc Clinical Investigation Inc
- DOI
- 10.1172/JCI121858
- PMID
- 29939163
- PMCID
- PMC6063499
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Number of pages
- 3
- Grant note
- R01HL118742 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32 HL007344; R01 HL118742 / National Heart, Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32GM007337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 08/01/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359947802771
Metrics
17 Record Views