Journal article
Fibrinolytic treatment for acute ischaemic stroke
Expert opinion on pharmacotherapy, Vol.7(3), pp.287-296
02/01/2006
DOI: 10.1517/14656566.7.3.287
PMID: 16448323
Abstract
Ischaemic stroke is a leading cause of death and disability in the US. At present, intravenous administration of tissue plasminogen activator within 3 h of symptom onset is the only proven effective treatment for patients with acute ischaemic stroke. Unfortunately, most treated patients do not make a functional recovery and very few patients presenting with acute stroke qualify for intravenous tissue plasminogen activator therapy. The focus of current research is to extend the therapeutic window for intervention beyond 3 h, and to improve the outcome of treated patients. The purpose of the present paper is to describe the current state of affairs for intravenous plasminogen activators, and to review recently published research. Agents and strategies under investigation include the intra-arterial delivery of plasminogen activators or antiplatelet agents, as well as combined intravenous/intra-arterial protocols.
Details
- Title: Subtitle
- Fibrinolytic treatment for acute ischaemic stroke
- Creators
- Avi Mazumdar - 1Instructor, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USAColin P Derdeyn - 2Associate Professor, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA. derdeync@wustl.edu
- Resource Type
- Journal article
- Publication Details
- Expert opinion on pharmacotherapy, Vol.7(3), pp.287-296
- Publisher
- Ashley Publications
- DOI
- 10.1517/14656566.7.3.287
- PMID
- 16448323
- ISSN
- 1465-6566
- eISSN
- 1744-7666
- Language
- English
- Date published
- 02/01/2006
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984013921202771
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