Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions

Manish Ora; Neetu Soni; Aftab Hasan Nazar; Manish Dixit; Rohit Singh; Savita Puri; Michael M Graham; Sanjay Gambhir

doi:10.2967/jnumed.123.265594

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Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions

Journal article

Open access

Peer reviewed

Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions

Manish Ora, Neetu Soni, Aftab Hasan Nazar, Manish Dixit, Rohit Singh, Savita Puri, Michael M Graham and Sanjay Gambhir

The Journal of nuclear medicine (1978), Vol.64(7), pp.1001-1008

07/01/2023

DOI: 10.2967/jnumed.123.265594

PMID: 37268422

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Abstract

Metastatic malignancies have limited management strategies and variable treatment responses. Cancer cells develop beside and depend on the complex tumor microenvironment. Cancer-associated fibroblasts, with their complex interaction with tumor and immune cells, are involved in various steps of tumorigenesis, such as growth, invasion, metastasis, and treatment resistance. Prooncogenic cancer-associated fibroblasts emerged as attractive therapeutic targets. However, clinical trials have achieved suboptimal success. Fibroblast activation protein (FAP) inhibitor–based molecular imaging has shown encouraging results in cancer diagnosis, making them innovative targets for FAP inhibitor–based radionuclide therapies. This review summarizes the results of preclinical and clinical FAP-based radionuclide therapies. We will describe advances and FAP molecule modification in this novel therapy, as well as its dosimetry, safety profile, and efficacy. This summary may guide future research directions and optimize clinical decision-making in this emerging field.

Details

Title: Subtitle: Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions
Creators: Manish Ora - Sanjay Gandhi Post Graduate Institute of Medical Sciences
Neetu Soni - University of Rochester Medical Center
Aftab Hasan Nazar - Sanjay Gandhi Post Graduate Institute of Medical Sciences
Manish Dixit - Sanjay Gandhi Post Graduate Institute of Medical Sciences
Rohit Singh - University of Vermont Medical Center
Savita Puri - University of Rochester Medical Center
Michael M Graham - University of Iowa
Sanjay Gambhir - Sanjay Gandhi Post Graduate Institute of Medical Sciences
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.64(7), pp.1001-1008
DOI: 10.2967/jnumed.123.265594
PMID: 37268422
NLM abbreviation: J Nucl Med
eISSN: 1535-5667
Language: English
Electronic publication date: 06/02/2023
Date published: 07/01/2023
Academic Unit: Radiology; Radiation Oncology
Record Identifier: 9984426745002771

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