Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

Lucas D BonDurant; Matthew J Potthoff

doi:10.1146/annurev-nutr-071816-064800

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Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

Journal article

Peer reviewed

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

Lucas D BonDurant and Matthew J Potthoff

Annual review of nutrition, Vol.38(1), pp.173-196

08/21/2018

DOI: 10.1146/annurev-nutr-071816-064800

PMCID: PMC6964258

PMID: 29727594

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Abstract

Fibroblast growth factor 21 (FGF21) is an endocrine hormone derived from the liver that exerts pleiotropic effects on the body to maintain overall metabolic homeostasis. During the past decade, there has been an enormous effort made to understand the physiological roles of FGF21 in regulating metabolism and to identify the mechanism for its potent pharmacological effects to reverse diabetes and obesity. Through both human and rodent studies, it is now evident that FGF21 levels are dynamically regulated by nutrient sensing, and consequently FGF21 functions as a critical regulator of nutrient homeostasis. In addition, recent studies using new genetic and molecular tools have provided critical insight into the actions of this endocrine factor. This review examines the numerous functions of FGF21 and highlights the therapeutic potential of FGF21-targeted pathways for treating metabolic disease.

Gene Expression Regulation - drug effects

Fibroblast Growth Factors - metabolism

Animals

Ethanol - metabolism

Homeostasis - physiology

Humans

Gene Expression Regulation - physiology

Food Deprivation

Lipid Metabolism - physiology

Details

Title: Subtitle: Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
Creators: Lucas D BonDurant - Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA; email: matthew-potthoff@uiowa.edu
Matthew J Potthoff - Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA; email: matthew-potthoff@uiowa.edu
Resource Type: Journal article
Publication Details: Annual review of nutrition, Vol.38(1), pp.173-196
DOI: 10.1146/annurev-nutr-071816-064800
PMID: 29727594
PMCID: PMC6964258
NLM abbreviation: Annu Rev Nutr
ISSN: 0199-9885
eISSN: 1545-4312
Publisher: United States
Grant note: R01 DK106104 / NIDDK NIH HHS T32 GM067795 / NIGMS NIH HHS
Language: English
Date published: 08/21/2018
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984040003102771

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