Journal article
Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway
FEBS letters, Vol.545(2), pp.173-176
2003
DOI: 10.1016/S0014-5793(03)00527-1
PMID: 12804770
Abstract
We studied the effects of fibroblast growth factor (FGF-10) on alveolar epithelial cell (AEC) Na,K-ATPase regulation. Within 30 min FGF-10 increased Na,K-ATPase activity and α1 protein abundance by 2.5-fold at the AEC plasma membrane. Pretreatment of AEC with the mitogen-activated protein kinase (MAPK) inhibitor U0126, a Grb2-SOS inhibitor (SH3-b-p peptide), or a Ras inhibitor (farnesyl transferase inhibitor (FTI 277)), as well as N17-AEC that express a Ras dominant negative protein each prevented FGF-10-mediated Na,K-ATPase recruitment to the AEC plasma membrane. Accordingly, we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway.
Details
- Title: Subtitle
- Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway
- Creators
- D Upadhyay - Northwestern UniversityE Lecuona - Northwestern UniversityA Comellas - Northwestern UniversityD.W Kamp - Northwestern UniversityJ.I Sznajder - Northwestern University
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.545(2), pp.173-176
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0014-5793(03)00527-1
- PMID
- 12804770
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 2003
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984359853002771
Metrics
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