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Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection
Journal article   Open access   Peer reviewed

Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection

Ahmad Nehme, Liqi Shu, Marion Boulanger, Junyue Ma, Salter Arms, Daniel Mandel, Christopher R Leon Guerrero, Esther S H Kim, Nils Henninger, Jayachandra Muppa, …
JAMA network open, Vol.8(11), e2540800
11/03/2025
DOI: 10.1001/jamanetworkopen.2025.40800
PMCID: PMC12593120
PMID: 41196598
url
https://doi.org/10.1001/jamanetworkopen.2025.40800View
Published (Version of record) Open Access

Abstract

Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD and to determine whether FMD is associated with recurrent SCEAD. Design, Setting, and Participants This cohort study included patients from the Stroke Prevention in Cervical Artery Dissection (STOP-CAD) retrospective cohort study who presented from January 2015 to December 2022. This multicenter and international cohort included consecutive adult patients presenting at acute care hospitals and diagnosed with SCEAD in 63 sites in 16 countries. Data were analyzed from April to November 2024. Exposure Fibromuscular dysplasia was defined as either a history of FMD or presence of FMD on cervical or renal artery imaging. Main Outcomes and Measures Clinical and radiological correlates were compared between patients with and without FMD using logistic regression models. Rates of recurrent SCEAD by 24 months were compared using a Cox proportional hazards model. Results This study included 3714 patients with SCEAD (median [IQR] age, 47 [38-56] years; 1637 [44.1%] females), of whom 196 (5.3%) had FMD. Patients with FMD were older (aOR per 10 years, 1.28; 95% CI, 1.14-1.43) and more often female (aOR, 2.00; 95% CI, 1.45-2.75). They more often had a history of dissection involving a noncervical artery (aOR, 8.10; 95% CI, 2.64-24.83), a history of SCEAD (aOR, 2.05; 95% CI, 1.07-3.93), a recent upper respiratory tract infection (aOR, 2.40; 95% CI, 1.52-3.78), a cerebral aneurysm (aOR, 2.22; 95% CI, 1.22-4.06), or a history of migraines (aOR, 2.44; 95% CI, 1.75-3.40). On imaging, they were less likely to have a single vertebral artery dissection (aOR, 0.37; 95% CI, 0.25-0.55) or an occlusive dissection (aOR, 0.55; 95% CI, 0.38-0.78). Eighty-one patients experienced a recurrent SCEAD, of which 46 (56.8%) occurred in the first 3 months of follow-up. The 24-month risk of recurrent SCEAD was 7.7% (95% CI, 3.1%-12.2%) and 2.8% (95% CI, 2.1%-3.5%) in patients with and without FMD, respectively (aHR, 2.75; 95% CI, 1.46-5.18; P = .002). Conclusions and relevance In this cohort study of patients with SCEAD, FMD was associated with distinct correlates and a higher rate of recurrent SCEAD. These findings may help physicians in identifying and counseling patients with FMD and SCEAD.
 Adult Female Fibromuscular Dysplasia - complications Fibromuscular Dysplasia - epidemiology Humans Male Middle Aged Recurrence Retrospective Studies Risk Factors Vertebral Artery Dissection - epidemiology

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