Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Robert F Mullins; Marissa A Olvera; Abbot F Clark; Edwin M Stone

doi:10.1016/j.exer.2006.09.021

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Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Journal article

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Peer reviewed

Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Robert F Mullins, Marissa A Olvera, Abbot F Clark and Edwin M Stone

Experimental Eye Research, Vol.84(2), pp.378-380

2007

DOI: 10.1016/j.exer.2006.09.021

PMCID: PMC1800825

PMID: 17109857

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https://www.ncbi.nlm.nih.gov/pmc/articles/1800825View

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Abstract

Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

Bruch's membrane

fibulins

age-related macular degeneration

extracellular matrix

Details

Title: Subtitle: Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration
Creators: Robert F Mullins - Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Marissa A Olvera - Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Abbot F Clark - Glaucoma Research, Alcon Research, Ltd., Fort Worth, TX, USA
Edwin M Stone - Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Experimental Eye Research, Vol.84(2), pp.378-380
DOI: 10.1016/j.exer.2006.09.021
PMID: 17109857
PMCID: PMC1800825
NLM abbreviation: Exp Eye Res
ISSN: 0014-4835
eISSN: 1096-0007
Publisher: Elsevier Ltd
Language: English
Date published: 2007
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980010502771

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