Journal article
Filoviruses: One of These Things is (not) Like the Other
Viruses, Vol.7(10), pp.5172-5190
09/29/2015
DOI: 10.3390/v7102867
PMCID: PMC4632375
PMID: 26426036
Abstract
The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus pathogenesis. However, in comparison, the seven other known filovirus family members are significantly understudied. Many of these, including Marburgviruses and Ebolaviruses other than EBOV, are also highly virulent and fully capable of causing widespread epidemics. This review places the focus on these non-EBOV filoviruses, including known immunological and pathological data. The available animal models, research tools and currently available therapeutics will also be discussed along with an emphasis in the large number of current gaps in knowledge of these less highlighted filoviruses. It is evident that much research is yet to be done in order to bring the non-EBOV filovirus field to the forefront of current research and, importantly, to the development of more effective vaccines and therapeutics to combat potential future outbreaks.
Details
- Title: Subtitle
- Filoviruses: One of These Things is (not) Like the Other
- Creators
- Scott M Anthony - The University of Texas MD Anderson Cancer CenterSteven B Bradfute - University of New Mexico Hospital
- Resource Type
- Journal article
- Publication Details
- Viruses, Vol.7(10), pp.5172-5190
- DOI
- 10.3390/v7102867
- PMID
- 26426036
- PMCID
- PMC4632375
- NLM abbreviation
- Viruses
- ISSN
- 1999-4915
- eISSN
- 1999-4915
- Language
- English
- Date published
- 09/29/2015
- Academic Unit
- Pathology
- Record Identifier
- 9984185273802771
Metrics
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