Journal article
Fimbria-Fornix Transections Disrupt the Ontogeny of Delayed Alternation but Not Position Discrimination in the Rat
Behavioral neuroscience, Vol.105(3), pp.386-395
06/1991
DOI: 10.1037/0735-7044.105.3.386
PMID: 1863360
Abstract
In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the PD task within five 12-trial blocks of training. However, only sham-operated pups learned the DA task. In Experiment 2, performance of DA emerged between PND19 and PND27 in sham-operated pups but failed entirely to develop in pups with early lesions. In Experiment 3, fornix-transected pups that were given extended DA training (132 trials) on PND23-PND24 showed some improvement in performance but remained impaired in relation to sham-operated controls. These findings implicate the limbic system in the postnatal development of DA but not PD and suggest that dual-process theories of memory may be relevant to the psychobiology of cognitive development.
Details
- Title: Subtitle
- Fimbria-Fornix Transections Disrupt the Ontogeny of Delayed Alternation but Not Position Discrimination in the Rat
- Creators
- John H Freeman - University of North Carolina at Chapel HillMark E Stanton
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.105(3), pp.386-395
- Publisher
- American Psychological Association
- DOI
- 10.1037/0735-7044.105.3.386
- PMID
- 1863360
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Language
- English
- Date published
- 06/1991
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065862602771
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