Journal article
Financial Implication of Radioactive Iodine Therapy for Early-Stage Papillary Thyroid Cancer
Oncology, Vol.93(2), pp.122-126
01/01/2017
DOI: 10.1159/000466700
PMID: 28609768
Abstract
Objective: The aim of this study was to evaluate disease-specific survival and cost related to radioactive iodine therapy (RAI) utilization in patients with early-stage papillary thyroid carcinoma (PTC). Methods: This was a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database, 2004-2012. Results: A total of 38,374 patients with PTC were identified. Of those, 56.3% had adjuvant RAI. RAI administration was not associated with a survival advantage in patients with PTC stage I (hazard ratio [HR] 1.26, 95% confidence interval [CI] 0.11, 14.54; p = 0.85) or stage II (HR 0.50, 95% CI 0.05, 4.88; p = 0.55). Patients with PTC stage III who underwent adjuvant RAI had an improved survival (HR 0.30, 95% CI 0.10, 0.91; p = 0.033). In 2012, RAI was used in 45.5% of patients with stage I and in 71.4% of patients with stage II. The total expenditure on adjuvant RAI for PTC stage I throughout the study period was estimated to be USD 82.3 million with an annual average of USD 9.1 (+/- 2.0) million/year. If the decline rate in the utilization of RAI continued, the model projected that the annual expenditure would decrease by USD 0.14 million/year. Conclusion: There is a high prevalence of adjuvant RAI utilization for earlystage PTC that is causing financial burden on the health system with no evidence of survival benefit. (C) 2017 S. Karger AG, Basel.
Details
- Title: Subtitle
- Financial Implication of Radioactive Iodine Therapy for Early-Stage Papillary Thyroid Cancer
- Creators
- Zaid Al-Qurayshi - Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USADaniah Bu Ali - Tulane UniversitySudesh Srivastav - Tulane UniversityEmad Kandil - Tulane University
- Resource Type
- Journal article
- Publication Details
- Oncology, Vol.93(2), pp.122-126
- Publisher
- Karger
- DOI
- 10.1159/000466700
- PMID
- 28609768
- ISSN
- 0030-2414
- eISSN
- 1423-0232
- Number of pages
- 5
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984702819502771
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